15 documents found, page 1 of 2
An outlook on implantable biosensors for personalized medicine
Rebelo, Rita; Barbosa, Ana Isabel Ferreira; Correlo, V. M.; Reis, R. L.Biosensors are a fast-growing field, as they have been shown to be very helpful in our daily life, playing roles in industries such as agriculture, food safety, homeland security, bioprocessing, environmental monitoring, and industrial monitoring. Beyond these, the application of biosensing in medicine and biomedical engineering may have the highest potential for growth and for affecting human quality of life i...
Synthesis of Novel Methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates an...
Silva, Bruna R.; Rebelo, Rita; Rodrigues, Juliana M.; Xavier, Cristina P. R.; Vasconcelos, M. Helena; Queiroz, Maria João R. P.A series of novel functionalized methyl 3-(hetero)arylthieno[3,2-<i>b</i>]pyridine-2-carboxylates <b>2a</b>–<b>2h</b> were synthesized by C-C Pd-catalyzed Suzuki-Miyaura cross-coupling of methyl 3-bromothieno[3,2-<i>b</i>]pyridine-2-carboxylate with (hetero)aryl pinacol boranes, trifluoro potassium boronate salts or boronic acids. Their antitumoral potential was evaluated in two triple negative breast cancer (T...
Aging Effect on Functionalized Silver-Based Nanocoating Braided Coronary Stents
Rebelo, Rita; Padrão, Jorge; Fernandes, Margarida M.; Carvalho, Sandra; Henriques, Mariana; Zille, Andrea; Fangueiro, RaulA previously developed fiber-based polyester (PES) stent, with mechanical properties comparable to commercial nitinol stents, was coated with metallic silver (Ag0) and silver oxides (AgxO) thin films through direct current (DC) magnetron sputtering. Ag0 and AgxO coatings provide antimicrobial properties to the stents to minimize the occurrence of coronary stent infections. Nevertheless, the stent interacts with...
Skin-Integrated wearable systems and implantable biosensors: a comprehensive re...
Rodrigues, Daniela; Barbosa, Ana I.; Rebelo, Rita; Kwon, Il Keun; Reis, R. L.; Correlo, V. M.Biosensors devices have attracted the attention of many researchers across the world. They have the capability to solve a large number of analytical problems and challenges. They are future ubiquitous devices for disease diagnosis, monitoring, treatment and health management. This review presents an overview of the biosensors field, highlighting the current research and development of bio-integrated and implant...
Bioceramics for osteochondral tissue engineering and regeneration
Pina, Sandra Cristina Almeida; Rebelo, Rita; Correlo, V. M.; Reis, R. L.; Oliveira, J. M.Considerable advances in tissue engineering and regeneration have been accomplished over the last decade. Bioceramics have been developed to repair, reconstruct, and substitute diseased parts of the body and to promote tissue healing as an alternative to metallic implants. Applications embrace hip, knee, and ligament repair and replacement, maxillofacial reconstruction and augmentation, spinal fusion, bone fill...
Influence of oxygen content on the antibacterial effect of Agx-Ox coatings depo...
Rebelo, Rita; Fangueiro, Raúl; Henriques, Mariana; Carvalho, S.Ag and AgOx thin films were deposited by pulsed DC magnetron sputtering, for stents devices, in order to provide antibacterial properties. During the deposition process, oxygen flow was varied (0-15 sccm) to understand the influence of oxygen species in the physical, chemical and structural properties of thin films. Coatings morphology was observed by scanning electron microscopy (SEM) and their nanostructure a...
Morphology and oxygen incorporation effect on antimicrobial activity of silver ...
Rebelo, Rita; Manninen, N. K.; Fialho, Luísa; Henriques, Mariana; Carvalho, SandraAg and AgxO thin films were deposited by non-reactive and reactive pulsed DC magnetron sputtering, respectively, with the final propose of functionalizing the SS316L substrate with antibacterial properties. The coatings were characterized chemically, physically and structurally. The coatings nanostructure was assessed by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), while the coatings morp...
Influence of design parameters on the mechanical behavior and porosity of braid...
Rebelo, Rita; Vila, Nívea Taís; Fangueiro, Raúl; Carvalho, Sandra; Rana, SohelIn spite of all innovations in stent design, commonly used metallic stents present several problems such as corrosion, infection and restenosis, leading to health complications or even death of patients. In this context, the present paper reports a systematic investigation on designing and development of 100% fiber based stents, which can eliminate or minimize the problems with existing metallic stents. For thi...
Methods of incorporation antimicrobial agents in stents
Rebelo, Rita; Fangueiro, Raúl; Carvalho, Sandra; Henriques, Mariana; Rana, SohelCommercial stents commonly used nowadays, especially metallic ones, present several disadvantages, such as corrosion, infection and restenosis, leading to health complications for the patient, or even to his death. Although there are different kinds of stents, like pharmacological stents, that can deliver drugs, there is not an “ideal” stent being able to avoid these disadvantages, of commercial ones. Thus, in ...
Development of braided fiber-based stents
Rebelo, Rita; Vila, Nívea Taís; Fangueiro, Raúl; Carvalho, Sandra Maria Fernandes; Henriques, MarianaThe mechanical behavior of stentsis one of the important factors involved in ensuring their function in maintaining an open blood vessel. This study aims to study the development of different kinds of fiber-based stents, using braiding technology. Moreover, the impact of braiding angle and mandrel’s diameter in the mechanical behavior of the stent is also analyzed. Furthermore, stent’s mechanical properties lik...