6 documents found, page 1 of 1
Chitosan micro-membranes with integrated gold nanoparticles as an LSPR-based se...
Meira, Diana Isabela Faria; Proença, Maria Manuela Carvalho; Rebelo, Rita Daniela Nogueira; Barbosa, Ana Isabel Ferreira; Rodrigues, Marco S.Currently, there is an increasing need to develop highly sensitive plasmonic sensors able to provide good biocompatibility, flexibility, and optical stability to detect low levels of analytes in biological media. In this study, gold nanoparticles (Au NPs) were dispersed into chitosan membranes by spin coating. It has been demonstrated that these membranes are particularly stable and can be successfully employed...
Current nanotechnology advances in diagnostic biosensors
Barbosa, Ana Isabel Ferreira; Rebelo, Rita Daniela Nogueira; Reis, R. L.; Bhattacharya, M.; Correlo, V. M.Current diagnostics present challenges that are imposed by increased life expectancy in the worldwide population. These challenges are related, not only to satisfy the need for higher performance of diagnostic tests, but also to the capacity of creating pointâ ofâ care, wearable, multiplexing and implantable diagnostic platforms that will allow early detection, continuous monitoring and treatment of health cond...
Aging effect on functionalized silver-based nanocoating braided coronary stents
Rebelo, Rita Daniela Nogueira; Padrão, Jorge; Fernandes, Margarida Maria Macedo; Carvalho, S.; Henriques, Mariana; Zille, Andrea; Fangueiro, RaúlA previously developed fiber-based polyester (PES) stent, with mechanical properties comparable to commercial nitinol stents, was coated with metallic silver (Ag0) and silver oxides (AgxO) thin films through direct current (DC) magnetron sputtering. Ag0 and AgxO coatings provide antimicrobial properties to the stents to minimize the occurrence of coronary stent infections. Nevertheless, the stent interacts with...
Development of label-free plasmonic Au-TiO2 thin film immunosensor devices
Barbosa, Ana Isabel Ferreira; Borges, Joel Nuno Pinto; Meira, Diana Isabela Faria; Costa, Diogo Emanuel Carvalho; Rodrigues, Marco S.This work reports on the development of a label-free immunosensor technology, based on nanoplasmonic Au-TiO2 thin films. The Au-TiO2 thin films were prepared by cost-effective reactive DC magnetron sputtering, followed by a thermal annealing procedure. The latter promoted the growth of the Au nanoparticles throughout the TiO2 matrix and induced some morphological changes, which are the base for the immunosensor...
3D biosensors in advanced medical diagnostics of high mortality diseases
Rebelo, Rita Daniela Nogueira; Barbosa, Ana I.; Caballero, David; Kwon, Il Keun; Oliveira, J. M.; Kundu, Subhas C; Reis, R. L.; Correlo, V. M.Cardiovascular diseases, cancer, and diabetes are high mortality diseases, which account for almost two thirds of all deaths worldwide. Their early detection and continuous evaluation is fundamental for an improved patient prognosis and reduced socioeconomic impact. Current biosensor technologies are typically based on the analysis of whole blood samples from patients for the detection of disease-specific bioma...
Fibrous braided stents with antibacterial properties
Rebelo, Rita Daniela NogueiraNowadays, cardiovascular diseases are reported as a major cause of death and disability in developed countries. Therefore, stents have emerged as a solution to overcome this problem. However, common commercialize stents, are metallic, which present several disadvantages as corrosion, higher risk of restenosis and infection. In order to minimize the disadvantages associated with these stents, new materials, like...