6 documents found, page 1 of 1
COVID-19: impact on Public Health and hypothesis-driven investigations on genet...
David, Suzana; Dorado, Guillermo; Duarte, Elsa Leclerc; David-Bosne, Stephanie; Trigueiro-Louro, João; Rebelo de Andrade, HelenaCOVID-19 is a new complex multisystem disease caused by the novel coronavirus SARS-CoV-2. In slightly over 2 years, it infected nearly 500 million and killed 6 million human beings worldwide, causing an unprecedented coronavirus pandemic. Currently, the international scientific community is engaged in elucidating the molecular mechanisms of the pathophysiology of SARS-CoV-2 infection as a basis of scientific de...
1st meeting of science and health museums and institutes of Lisbon metropolitan...
Ferraz, Amélia Ricon; Carneiro, Ana; Delicado, Ana; Cascais, António Fernando; Nunes, Fátima; Gonçalves Pinto, Helena; Rebelo de Andrade, Helena.
Reverse genetics vaccine seeds for influenza: Proof of concept in the source of...
Gíria, Marta; Santos, Luís; Louro, João; Rebelo de Andrade, HelenaGrowth deficits of reverse genetics vaccine seeds have compromised effective immunization. The impairment has been attributed to sub-optimal protein interactions. Some level of dependence may exist between PB1 and antigenic glycoproteins, however, further research is necessary to clarify the extent to which it can be used in favor of seed production. Our objective was to establish proof of concept on the phenot...
A cost-efficient solution: reagent comparison guide for neuraminidase inhibitio...
Louro, João; Correia, Vanessa; Rebelo de Andrade, HelenaObjectives: Compare available alternative reagents for Neuraminidase Activity Assay and Neuraminidase Inhibition Assay; Assess the phenotypic susceptibility profiles of influenza viruses from different (sub)types to the new Neuraminidase Inhibitors: laninamivir and peramivir.
Uncovering the role of positive selection in the evolutionary pathways to influ...
Correia, Vanessa; Abecasis, Ana; Rebelo de Andrade, HelenaThis study aimed at estimating the site-specific SP on the NA gene of currently circulating human influenza viruses, in order to infer the SP acting specifically on the sites associated with (H)RI by NAIs and on further sites contacting directly or indirectly with the drug (active site). The frequency of drug-resistant and (H)RI variants was determined as a secondary objective, prompted by the need of determini...
Functional compatibility of PB1 and antigenic proteins as a determinant of vira...
Gíria, Marta; Louro, João; Rebelo de Andrade, HelenaObjectives: To determine if the functional compatibility between PB1 and antigenic proteins is a molecular determinant of virus growth and antigen yield in PR8:A(H1N1)pdm09 reassortants; To evaluate the phenotypic expression of reverting mutations R386K, I517V and L298I, previously identified as putatively associated with an enhanced functional compatibility between PB1 and HA in the A(H1N1)pdm09