Encontrados 31 documentos, a visualizar página 1 de 4
Flavonoid Derivatives Targeting BCR-ABL Kinase: Semisynthesis, Molecular Dynami...
Ribeiro, Rayssa; Eloy, Mariana A.; Francisco, Carla S.; Javarini, Clara L.; Ayusso, Gabriela M. [UNESP]; Fonseca, Victor Da Rocha; Romão, WandersonMade available in DSpace on 2022-04-28T19:48:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Background: Natural products have been universally approached in the research of novel trends useful to detail the essential paths of the life sciences and as a stra...
Design, synthesis and antibacterial activity of chalcones against MSSA and MRSA...
Garcia, Mayara A.R. [UNESP]; Theodoro, Reinaldo S. [UNESP]; Sardi, Janaina C.O.; Santos, Mariana B. [UNESP]; Ayusso, Gabriela M. [UNESP]Made available in DSpace on 2022-04-29T08:32:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; Staphylococcus aureus is the one of the most successful modern pathogens. The same bacterium that lives as a skin and mucosal commensal can be transmitted in health-care and community-settings and causes severe infections. Thus, there is a great challenge for a discovery of novel anti-Staphylococcus aur...
Radical scavenging capacity of Piper arboreum and Piper tuberculatum (Piperaceae)
Regasini, Luis O. [UNESP]; Cotinguiba, Fernando [UNESP]; Siqueira, Janaina R. [UNESP]; Bolzani, Vanderlan S. [UNESP]; Silva, Dulce H.S. [UNESP]Made available in DSpace on 2022-04-28T20:51:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-12-01; In the scope of our ongoing researchers on antioxidant compounds, twenty four extracts and fractions obtained from Piper arboreum Aublet and Piper tuberculatum Jacq. (Piperaceae) were screened for radical scavenging capacity (RSC) by using DPPH colorimetric assay. The strongest activity was found in eth...
Alcohol extract of Pterogyne nitens leaves fails to reduce severity of streptoz...
de Souza, Aline [UNESP]; Vendramini, Regina C. [UNESP]; Brunetti, Iguatemy L. [UNESP]; Regasini, Luis O. [UNESP]; Siqueira Silva, Dulce H. [UNESP]Made available in DSpace on 2022-04-28T21:01:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-05-01; Two constituents of Pterogyne nitens leaves, kaempferitrin, a diglycosylated flavonol, and galegin, a guanidine alkaloid, may be considered likely to exert an antidiabetic effect, on the basis of their chemical structures. Thus, experimentally diabetic rats were treated with P. nitens leaf extract, to o...
Curcumin-cinnamaldehyde hybrids as antiproliferative agents against women’s can...
Anselmo, Daiane B. [UNESP]; Polaquini, Carlos R. [UNESP]; Marques, Beatriz C. [UNESP]; Ayusso, Gabriela M. [UNESP]; Assis, Letícia R. [UNESP]Made available in DSpace on 2022-05-01T08:44:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Curcumin and cinnamaldehyde are natural products whose antineoplastic activity has been well explored in biological evaluations. However, their poor chemical stability under physiological conditions has been an obstacle to their use as therapeutic agents. Herein, we designed and synthesized two series o...
Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ame...
de Morandim-Giannetti, Andreia A. [UNESP]; Cotinguiba, Fernando [UNESP]; Regasini, Luis O. [UNESP]; Frigieri, Mariana C. [UNESP]Made available in DSpace on 2022-04-28T22:48:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-06-15; Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (...
Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A
Morao, Luana G. [UNESP]; Lorenzoni, Andre S. G.; Chakraborty, Parichita; Ayusso, Gabriela M. [UNESP]; Cavalca, Lucia B.; Santos, Mariana B. [UNESP]Made available in DSpace on 2021-06-25T12:23:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Xanthomonas citri subsp. citri (X. citri) is an important phytopathogen and causes Asiatic Citrus Canker (ACC). To...
Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associ...
Polaquini, Carlos R. [UNESP]; Marques, Beatriz C. [UNESP]; Ayusso, Gabriela M. [UNESP]; Morão, Luana G. [UNESP]; Sardi, Janaína C.O.Made available in DSpace on 2021-06-25T10:52:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic application. Monocarbonyl analogs of curcumin (MACs) have bee...
Identification of a Prenyl Chalcone as a Competitive Lipoxygenase Inhibitor: Sc...
Zeraik, Maria Luiza [UNESP]; Pauli, Ivani; Dutra, Luiz A. [UNESP]; Cruz, Raquel S. [UNESP]; Valli, Marilia [UNESP]; Paracatu, Luana C. [UNESP]Made available in DSpace on 2021-06-25T10:59:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-12; Fundação Araucária; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Cyclooxygenase (COX) and lipoxygenase (LOX) are key targets for the development of new anti-inflammatory agents. LOX, which is involved in the biosynth...
Methoxychalcones: Effect of methoxyl group on the antifungal, antibac-terial an...
Marques, Beatriz C. [UNESP]; Santos, Mariana B. [UNESP]; Anselmo, Daiane B. [UNESP]; Monteiro, Diego A. [UNESP]; Gomes, Eleni [UNESP]Made available in DSpace on 2020-12-12T02:47:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background: Chalcones substituted by methoxyl groups have presented a broad spec-trum of bioactivities...