5 documents found, page 1 of 1
Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Vieira,Gabriela Alves Licursi; Silva,Marco Túlio Alves da; Regasini,Luis Octávio; Cotinguiba,Fernando; Laure,Helen Julie; Rosa,José César; Furlan,MaysaABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effecti...
Trypanocidal activity of Brazilian plants against epimastigote forms from Y and...
Alves,Renata Tomé; Regasini,Luis Octávio; Funari,Cristiano Soleo; Young,Maria Cláudia Marx; Rimoldi,Aline; Bolzani,Vanderlan da SilvaChagas disease is one of the main public health problems in Latin America. Since the available treatments for this disease are not effective in providing cure, the screening of potential antiprotozoal agents is essential, mainly of those obtained from natural sources. This study aimed to provide an evaluation of the trypanocidal activity of 92 ethanol extracts from species belonging to the families Annonaceae, ...
Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunisti...
Regasini,Luis Octávio; Pivatto,Marcos; Scorzoni,Liliana; Benaducci,Tatiane; Fusco-Almeida,Ana Marisa; Giannini,Maria José Soares MendesAs part of our ongoing research on antifungal agents from Brazilian flora, eight extracts and twelve fractions from Pterogyne nitens Tul., Fabaceae, were screened for antimicrobial activity against four opportunistic fungi species (Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans) using a broth microdilution method. The present investigation reveals that P. nitens extracts and ...
Trypanocidal activity of Piper arboreum and Piper tuberculatum (Piperaceae)
Regasini,Luis Octávio; Cotinguiba,Fernando; Passerini,Gabriela Duó; Bolzani,Vanderlan da Silva; Cicarelli,Regina Maria Barretto; Kato,Massuo JorgeIn the scope of our ongoing research on bioactive agents from Brazilian flora, twenty-four extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for trypanocidal activity by using MTT colorimetric assay. The strongest activity was found in hexane fractions from the leaves of P. arboreum (IC50= 13.3 µg/ mL) and P. tuberculatum (IC50 = 17.2 µg/mL). Hexane...
Constituintes químicos das flores de Pterogyne nitens (Caesalpinioideae)
Regasini,Luis Octávio; Fernandes,Daniara Cristina; Castro-Gamboa,Ian; Silva,Dulce Helena Siqueira; Furlan,Maysa; Bolzani,Vanderlan da SilvaThe phytochemical investigation of the flowers of Pterogyne nitens (Caesalpinioideae) resulted in the isolation and identification of nine phenolic derivatives, quercetin 3-O-sophoroside, taxifolin, astilbin, ourateacatechin, caffeic, ferulic, sinapic, chlorogenic and gallic acid, besides two guanidine alkaloids, pterogynine, pterogynidine. This is the first time these compounds have been reported in P. nitens ...