2 documents found, page 1 of 1
Promoting advanced medical services in the framework of 3PM-a proof-of-concept ...
Regateiro, Fernando J; Silva, Henriqueta Alexandra Mendes Breda Lobo Coimbra; Lemos, Manuel C.; Moura, GabrielaMultidisciplinary team from three universities based in the "Centro" Region of Portugal developed diverse approaches as parts of a project dedicated to enhancing and expanding Predictive, Preventive, and Personalized Medicine (3PM) in the Region. In a sense, outcomes acted as a proof-of-concept, in that they demonstrated the feasibility, but also the relevance of the approaches. The accomplishments comprise def...
CYP2D6 genetic polymorphisms are associated with susceptibility to pituitary tu...
Gomes, Leonor; Lemos, Manuel C; Paiva, Isabel; Ribeiro, Cristina; Carvalheiro, Manuela; Regateiro, Fernando JSeveral polymorphisms of drug-metabolizing enzymes have been implicated in the susceptibility to tumor development. The role of the CYP2D6, GSTM1 and GSTT1 genes has been extensively studied, with alleles conferring different metabolic efficiencies and tumor risk. We studied the relationship between the main polymorphisms of these genes and the susceptibility to develop pituitary tumors, by performing a case-co...