39 documents found, page 1 of 4
Identifying imprints of externally derived dust and halogens in the sedimentary...
Moreno, J.; Ramos, A. M.; Raposeiro, P. M.; Santos, R. N.; Rodrigues, T.; Naughton, F.; Moreno, F.; Trigo, R. M.; Ibañez-Insa, J.; Ludwig, P.; Shi, X.Iberian lacustrine sediments are a valuable archive to document environmental changes since the last glacial termination, seen as key for anticipating future climate/environmental changes and their far-reaching implica -tions for generations to come. Herein, multi-proxy-based indicators of a mountain lake record from Serra da Estrela were used to reconstruct atmospheric (in)fluxes and associated climatic/enviro...
Influence of environmental variability and Emiliania huxleyi ecotypes on alkeno...
Rigual-Hernández, A.S.; Sierro, F.J.; Flores, J.A.; Trull, T.W.; Rodrigues, T.; Martrat, B.; Sikes, E.L.; Nodder, S.D.; Eriksen, R.S.; Davies, D.Long-chain unsaturated alkenones produced by haptophyte algae are widely used as paleotemperature indicators. The unsaturation relationship to temperature is linear at mid-latitudes, however, non-linear responses detected in subpolar regions of both hemispheres have suggested complicating factors in these environments. To assess the influence of biotic and abiotic factors in alkenone production and preservation...
Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminerg...
Tavares, G.; Marques, D.; Barra, C.; Rosendo-Silva, D.; Costa, A.; Rodrigues, T.; Gasparini, P.; Melo, B. F.; Sacramento, J. F.; Seiça, R.; Conde, S. V.The therapeutic effects of the dopamine D2 receptor (D2R) agonist, bromocriptine, in type 2 diabetes (T2D) have been attributed to central nervous system actions. However, peripheral dopamine directly modulates glucose uptake in insulin-sensitive tissues and lipid metabolism in adipose tissue (AT). We hypothesized that the dopaminergic system may be impaired in the adipose tissue of patients with T2D and that t...
Dietary Glycotoxins Impair Hepatic Lipidemic Profile in Diet-Induced Obese Rats...
Neves, C.; Rodrigues, T.; Sereno, J.; Simões, C.; Castelhano, J.; Gonçalves, J.; Bento, G.; Gonçalves, S.; Seiça, R.; Domingues, M. R. M.Nonalcoholic fatty liver disease (NAFLD) is caused by excessive liver lipid accumulation, but insulin resistance is specifically associated with impaired lipid saturation, oxidation, and storage (esterification), besides increased de novo lipogenesis. We hypothesized that dietary glycotoxins could impair hepatic lipid metabolism in obesity contributing to lipotoxicity-driven insulin resistance and thus to the o...
Anaerobic biological fermentation of urine as a strategy to enhance the perform...
Barbosa, Sónia G.; Rodrigues, T.; Peixoto, L.; Kuntke, Philipp; Alves, M. M.; Pereira, M. A.; Heijne, Annemiek TerThis study investigated the effect of pre-fermented urine on anode performance of a two-chambered microbial electrolysis cells (MECs) compared to raw urine. Pre-fermentation of urine was performed by anaerobic digestion. The effect of this pre-fermentation on anode performance of a MEC was assessed by measuring the removal of chemical oxygen demand (COD), current density and Coulombic efficiency (CE). The MEC u...
Dilated cardiomyopathy : a group that does not benefit from ICD?
Silverio Antonio, P.; Nunes-Ferreira, Afonso; Aguiar-Ricardo, Inês; Rigueira, Joana; Santos, R.; Rodrigues, T.; Cunha, N.; Morais, P. S.Introduction: The prevalence of sudden death in patients with heart failure with reduced ejection fraction has been declining in the last decade, not only due to better optimization of pharmacological therapy, but also due to the high rate of cardiac resynchronization responders. Overall, based on recent studies demonstrating a lack of improvement in mortality in some patients with dilated cardiomyopathy, the C...
iBox-CRT : better response, less complicated, equally fast
Aguiar-Ricardo, Inês; Nunes-Ferreira, Afonso; Rigueira, Joana; Agostinho, João R.; Santos, R.; Lima da Silva, G.; Antonio, Pedro Silverio; Rodrigues, T.Introduction: The optimization of the left ventricle (LV) pacing site guided by the electrical delay increases CRT response rate (RR), however it’s necessary to develop technology that allows its universal use. Purpose: The aim is automatically, and operator-independent, access the conduction delay between the right ventricular (RV) stimulus and the LV available veins in order to select the LV pacing site. It i...
Long-standing persistent atrial fibrillation : what can we achieve with ablation?
Nunes-Ferreira, Afonso; Cortez-Dias, Nuno; Silverio Antonio, P.; Silva, Gustavo Lima da; Gonçalves, Inês; Aguiar-Ricardo, Inês; Rigueira, JoanaIntroduction: Atrial fibrillation (AF) ablation presents suboptimal results in patients (pts) with persistent long-lasting forms (LSPAF, AF ≥12 months). Recently, the STAR AF-II trial has shown that in these pts complex additional strategies do not improve success compared to only performing pulmonary vein isolation (PVI). Objectives: To evaluate the success of AF ablation, particularly in long-standing persist...
An unusual cause of myocardial infarction
Cunha, N. P. D.; Rigueira, Joana; Rodrigues, T.; Aguiar-Ricardo, Inês; Sousa, I.; Campos, P.; Pinto, Fausto J.; Almeida, Ana G.Background: In order to direct the treatment it, is well established that is fundamental to clarify the aetiology of heart failure and the cause of myocardial infarction (MI) with non obstructive coronary artery disease (MINOCA), with CMR being one of the methods of choice in both clinical situations. Case report: A 70 years-old male patient was admitted in our emergency department with complaints of irregular ...
How can we improve the success of cardiac resynchronization therapy implantation?
Nunes-Ferreira, Afonso; Antonio Silverio, P.; Agostinho, João R.; Aguiar-Ricardo, Inês; Rigueira, Joana; Santos, R.; Cunha, N.; Rodrigues, T.Introduction: The left ventricular (LV) lead implantation in cardiac resynchronization therapy (CRT) is one of the most important and complex steps, leading to implantation failure in 10–15% of cases. New LV lead implantation techniques are needed to allow better resynchronization and decrease mortality and hospitalizations. Objectives: To evaluate the efficacy and safety of the snare technique in the LV lead i...