4 documents found, page 1 of 1
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collabor...
Zdouc, Mitja M.; Blin, Kai; Louwen, Nico L. L.; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D.; Bailey, Constance B.; Barra, LenaSpecialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readabl...
Mapping human pathogens in wastewater using a metatranscriptomic approach
Carneiro, João; Pascoal, Francisco; Semedo, Miguel; Pratas, Diogo; Tomasino, Maria Paola; Rego, Adriana; Carvalho, Maria de Fátima; Mucha, Ana PaulaThe monitoring of cities' wastewaters for the detection of potentially pathogenic viruses and bacteria has been considered a priority during the COVID-19 pandemic to monitor public health in urban environments. The methodological approaches frequently used for this purpose include deoxyribonucleic acid (DNA)/Ribonucleic acid (RNA) isolation followed by quantitative polymerase chain reaction (qPCR) and reverse t...
The Extremophile Endolithella mcmurdoensis gen. et sp. nov. (Trebouxiophyceae, ...
Martins, Teresa P.; Ramos, Vitor; Hentschke, Guilherme S.; Castelo-Branco, Raquel; Rego, Adriana; Monteiro, Maria; Brito, Ângela; Tamagnini, PaulaThe McMurdo Dry Valleys constitute the largest ice-free region of Antarctica and one of the most extreme deserts on Earth. Despite the low temperatures, dry and poor soils and katabatic winds, some microbes are able to take advantage of endolithic microenvironments, inhabiting the pore spaces of soil and constituting photosynthesis-based communities. We isolated a green microalga, Endolithella mcmurdoensis gen....
Actinobacteria and cyanobacteria diversity in terrestrial Antarctic microenviro...
Rego, Adriana; Raio, Francisco; Martins, Teresa P.; Ribeiro, Hugo; Sousa, António G.G.; Séneca, Joana; Baptista, Mafalda S.; Lee, Charles K.Bacterial diversity from McMurdo Dry Valleys in Antarctica, the coldest desert on earth, has become more easily assessed with the development of High Throughput Sequencing (HTS) techniques. However, some of the diversity remains inaccessible by the power of sequencing. In this study, we combine cultivation and HTS techniques to survey actinobacteria and cyanobacteria diversity along different soil and endolithi...