2 documents found, page 1 of 1
Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in ...
Monteiro, FA; Miranda, RM; Samina, MC; Dias, AF; Raposo, AASF; Oliveira, P; Reguenga, C; Castro, DS; Lima, DThe spinal cord dorsal horn is a major station for integration and relay of somatosensory information and comprises both excitatory and inhibitory neuronal populations. The homeobox gene Tlx3 acts as a selector gene to control the development of late-born excitatory (dILB) neurons by specifying glutamatergic transmitter fate in dorsal spinal cord. However, since Tlx3 direct transcriptional targets remain largel...
Neuropathic pain induced alterations in the opioidergic modulation of a descend...
Costa, AR; Carvalho, P; Flik, G; Wilson, S; Reguenga, C; Martins, I; Tavares, IOpioids play a major role at descending pain modulation but the effects of neuropathic pain on the brain opioidergic system remain understudied. Since descending facilitation is enhanced during neuropathic pain, we studied the opioidergic modulation of the dorsal reticular nucleus (DRt), a medullary pain facilitatory area, in the spared nerve injury (SNI) model of neuropathic pain. We first performed a series o...