30 documents found, page 1 of 3

Lower body parkinsonism

Background Magnetic resonance imaging (MRI) planimetric biomarkers such as the midbrain to pons (M/P) ratio, magnetic resonance parkinsonism index (MRPI), and MRPI 2.0 have demonstrated high diagnostic accuracy discriminating Progressive Supranuclear Palsy (PSP) patients from other atypical parkinsonisms and Parkinson’s Disease (PD). However, these indexes have not been studied in the specific context of lower ...

Rare Presentation of Gastric Cancer as Leptomeningeal Carcinomatosis and Inappr...

Leptomeningeal carcinomatosis (LC) and paraneoplastic syndrome of inappropriate antidiuretic hormone secretion (SIADH) are rarely associated with gastric cancer, especially as presenting forms of asymptomatic gastric cancer. An 87-year-old woman was admitted because of lethargy, mnesic deficit, disorientation and gait instability affecting her autonomy for 20 days. Laboratory tests were suggestive of SIADH, bod...

Neuroimaging Safety in Children

Paediatric neuroimaging is distinct from adult imaging, warranting dedicated approaches that take into account the singularities of this population in the selection of the appropriate imaging techniques for each phase of the normal development. The impact of ionising radiation exposure or contrast media usage need to be taken into account when planning or performing paediatric imaging, with risk versus benefit ...

Motivos de exclusão para a cirurgia de estimulação cerebral profunda na doença ...

Novel compound heterozygous variants of SPG11 gene associated with young-adult ...

SPG11 gene is localized on chromosome 15q21 and encodes spatacsin. Mutations of this gene are typically associated with autosomal recessive hereditary spastic paraplegia (HSP)-11, causing progressive spasticity of the lower limbs. This type of HSP is usually associated with other manifestations, such as thickness reduction of corpus callosum, cognitive impairment, peripheral neuropathy, pseudobulbar involvement...

Natural history of familial cerebral cavernous malformation syndrome in childre...

Purpose: There is limited data concerning neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors. Methods: We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric...

Spinal involvement in pediatric familial cavernous malformation syndrome

Purpose: The aim of the study was to assess the prevalence and characteristics of spinal cord cavernous malformations (SCCM) and intraosseous spinal vascular malformations (ISVM) in a pediatric familial cerebral cavernous malformation (FCCM) cohort and evaluate clinico-radiological differences between children with (SCCM +) and without (SCCM-) SCCM. Methods: All patients with a pediatric diagnosis of FCCM evalu...

Cardiovascular and cerebrovascular risk markers in Parkinson’s disease: results...

Background: The relationship between Parkinson's disease (PD) and cardiovascular and cerebrovascular disease is not yet well established. Recent data suggest an increased risk of myocardial infarction and stroke in PD patients. Therefore, we designed a study to assess surrogate markers of cardiovascular and cerebrovascular risk in PD. Methods: We conducted a case-control study comparing PD patients recruited fr...

A standardized MR Imaging protocol for Parkinsonism

Despite well-established Parkinson’s disease (PD) diagnostic criteria, diagnosis can still be challenging, with a high rate of misdiagnosis in atypical cases, especially in early disease stages. The majority of misdiagnoses are related to the differential diagnosis of PD with atypical parkinsonian disorders (APD), such as multiple system atrophy–parkinsonian type (MSA-P), progressive supranuclear palsy (PSP), o...

N‐Terminal Pro‐B‐type natriuretic peptide levels in Parkinson's disease

We read with interest the study by Choe and colleagues who increases emphasis on the heart–brain axis in Parkinson’s disease (PD). They have studied the relation between subclinical cardiac markers and motor impairment (Unifed Parkinson’s Disease Rating Scale Part III and Hoehn and Yahr stage) and cognition (Montreal Cognitive Assessment[MoCA]) concluding that patients with PD presented higher levels of N-termi...