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Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired O...

Pölkki, Anssi; Reinikainen, Matti; Rochwerg, Bram; Jung, Christian; Sendagire, Cornelius; Chaudhuri, Dipayan; Martin, Greg S.; Selander, Tuomas

Publisher Copyright: © 2025 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.; BACKGROUND: The ratio of arterial oxygen partial pressure to fraction of inspired oxygen (PaO2/FiO2, hereafter P/F ratio) is a key component of the Sequential Organ Failure Assessment (SOFA) score. It reflects the severity of hypoxaemic r...


Rationale and Methodological Approach Underlying the Development of the Sequent...

Moreno, Rui; Rhodes, Andrew; Ranzani, Otavio; Salluh, Jorge; Berger-Estilita, Joana; Coopersmith, Craig M.; Juffermans, Nicole P.; Laffey, John

Importance: The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over the last 3 decades in the use of organ support drugs and devices and in patient outcomes, necessitating revision of the score. Objectives: To develop definitions of organ dysf...


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