20 documents found, page 1 of 2
Locust bean gum (LBG) – a potential excipient for inhalation purposes: excipien...
Pontes, Jorge Filipe; Guerreiro, Filipa; da Silva, Joana Pinto; Almeida, Maria; Rosso, Annalisa; Rosa da Costa, Ana M; Agusti, GéraldineDry powders proposed for lung drug delivery typically involve excipients not approved for inhalation. The physicochemical characterisation of excipients is informative regarding their interaction with different body structures. Locust Bean Gum (LBG) has been proposed for diverse applications, including inhalation, benefiting from targeting ability towards phagocytic cells owing to the presence of mannose moieti...
The role of reactive oxygen species in bone cell physiology and pathophysiology
Carvalho, Adriana Marques; Kim, Ha-Neui; Almeida, MariaHydrogen peroxide (H2O2), superoxide anion radical (O2-•), and other forms of reactive oxygen species (ROS) are produced by the vast majority of mammalian cells and can contribute both to cellular homeostasis and dysfunction. The NADPH oxidases (NOX) enzymes and the mitochondria electron transport chain (ETC) produce most of the cellular ROS. Multiple antioxidant systems prevent the accumulation of excessive am...
The NAD salvage pathway in mesenchymal cells is indispensable for skeletal deve...
Warren, Aaron; Porter, Ryan M; Reyes-Castro, Olivia; Ali, Md Mohsin; Carvalho, Adriana Marques; Kim, Ha-Neui; Gatrell, Landon B; Schipani, ErnestinaNAD is an essential co-factor for cellular energy metabolism and multiple other processes. Systemic NAD+ deficiency has been implicated in skeletal deformities during development in both humans and mice. NAD levels are maintained by multiple synthetic pathways but which ones are important in bone forming cells is unknown. Here, we generate mice with deletion of Nicotinamide Phosphoribosyltransferase (Nampt), a ...
Eficácia da intervenção da osteopatia nas disfunções ginecológicas: uma revisão...
Fernandes, Ângela; Ferreira, Inês; Almeida, Maria; Boaventura, Maria Francisca; Sousa, Helena; Campelo, NataliaOs distúrbios ginecológicos apresentam elevada prevalência e têm como possíveis consequências o aumento da dor e a diminuição da qualidade de vida. Apesar do tratamento ser maioritariamente farmacológico, cada vez mais a osteopatia se tem afirmado como uma forma de tratamento válida e eficaz. Sistematizar os ensaios clínicos randomizados de forma a verificar a eficácia da intervenção osteopática na dor e qualid...
PRINCIPAIS DESAFIOS NO ENSINO-APRENDIZAGEM DE BOTÂNICA NA VISÃO DE UM GRUPO DE ...
Oliveira, Auta; Cruz, Renata; Almeida, Maria; Alves, AnaSubmitted by Yanna Sousa (yanna_gomes@yahoo.com.br) on 2021-08-04T12:10:11Z No. of bitstreams: 2 Ata de defesa_Auta Paulina da Silva.pdf: 168939 bytes, checksum: e6188309caec51eff7b871f550713913 (MD5) PRINCIPAIS DESAFIOS NO ENSINO-APRENDIZAGEM DE BOTÂNICA NA VISÃO DE UM GRUPO DE PROFESSORES DA EDUCAÇÃO BÁSICA_Auta Paulina.pdf: 677067 bytes, checksum: f2678be7a4021f152928b7f4bc569275 (MD5); Approved for entry in...
Estrogens decrease osteoclast number by attenuating mitochondria oxidative phos...
Kim, Ha-Neui; Ponte, Filipa; Nookaew, Intawat; Ucer Ozgurel, Serra; Carvalho, Adriana Marques; Iyer, Srividhya; Warren, Aaron; Aykin-Burns, NukhetLoss of estrogens at menopause is a major cause of osteoporosis and increased fracture risk. Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. Here, we investigated the molecular mechanism of this effect. We report that 17β-estradiol (E2) decreased osteoclast number by promoting the apoptosis of early osteoclast progenitors, but not matur...
Effects of caregiver-provided individual cognitive interventions on cognition, ...
Silva, Rosa; Bobrowicz-Campos, Elzbieta; Cardoso, Daniela; Costa, Paulo; Couto, Filipa; Camarneiro, Ana Paula; Abrunheiro, Sérgio; Almeida, MariaObjective: The objective of this review was to investigate the effectiveness of caregiver-provided individual cognitive interventions for improving cognition, social functioning and quality of life in older adults with major neurocognitive disorders. Introduction: A large number of people with major neurocognitive disorders live in their homes, requiring ongoing community care. Different individual cognitive in...
Efeitos de um programa de estimulação cognitiva em idosos institucionalizados
Parola, Vítor; Coelho, Adriana; Neves, Hugo; Almeida, Maria; Gil, Isabel; Mouro, Ana; Apóstolo, JoãoEnquadramento: A evidencia sugere que a estimulação cognitiva nos idosos tem resultados positivos na cognição e na sintomatologia depressiva. Objetivo: Avaliar a eficácia de um programa de estimulação cognitiva na cognição e sintomatologia depressiva em idosos institucionalizados. Metodologia: Estudo experimental numa amostra de 100 idosos. A versao portuguesa da Mini-Mental State Examination e da Geriatric Dep...
Effects of a cognitive stimulation program on institutionalized older people
Parola, Vítor; Coelho, Adriana; Neves, Hugo; Almeida, Maria; Gil, Isabel; Mouro, Ana; Apóstolo, JoâoEnquadramento: A evidência sugere que a estimulação cognitiva nos idosos tem resultados positivos na cognição e na sintomatologia depressiva. Objetivo: Avaliar a eficácia de um programa de estimulação cognitiva na cognição e sintomatologia depressiva em idosos institucionalizados. Metodologia: Estudo experimental numa amostra de 100 idosos. A versão portuguesa da Mini-Mental State Exami- nation e da Geriatric D...
Efficacy of reminiscence in cognition, depressive symptoms and quality of life ...
Gil, Isabel; Costa, Paulo; Parola, Vítor; Cardoso, Daniela; Almeida, Maria; Apóstolo, JoãoObjective: To identify the best available evidence on the efficacy of Reminiscence Therapy in cognition, depressive symptoms and quality of life in elderly individuals with cognitive impairment. Method: The methodology proposed by the Joanna Briggs Institute was used. Studies focused on group Reminiscence Therapy aimed at institutionalized elderly people with cognitive impairment aged 65 or over were considered...