Encontrados 75 documentos, a visualizar página 1 de 8
Field and classroom initiatives for portable sequence-based monitoring of dengu...
Adelino, Talita ?mile Ribeiro; Giovanetti, Marta; Fonseca, Vagner; Xavier, Joilson; Abreu, ?lvaro Salgado de; Nascimento, Valdinete Alves doThis work was supported by Decit, SCTIE, Brazilian Ministry of Health, Conselho Nacional de Desenvolvimento Cient?fico - CNPq (440685/ 2016-8, 440856/2016-7 and 421598/2018-2), Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES - (88887.130716/2016-00), European Union?s Horizon 2020 Research and Innovation Programme under ZIKAlliance Grant Agreement (734548), STARBIOS (709517), Funda??o de Ampa...
Synthetic peptides elicit strong cellular immunity in Visceral Leishmaniasis na...
Brito, Rory Cristiane Fortes de; Cardoso, Jamille Mirelle de Oliveira; Reis, Levi Eduardo Soares; Mathias, Fernando Augusto SiqueiraReverse vaccinology or immunoinformatics is a computational methodology which integrates data from in silico epitope prediction, associated to other important information as, for example, the predicted subcellular location of the proteins used in the design of the context of vaccine development. This approach has the potential to search for new targets for vaccine development in the predicted proteome of pathog...
Performance of recombinant chimeric proteins in the serological diagnosis of Tr...
Leony, Leonardo Maia; Freitas, Natália Erdens Maron de; Del-Rei, Rodrigo Pimenta; Carneiro, Cláudia Martins; Reis, Alexandre Barbosa; Jansen, Ana MariaBackground: Dogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method of choice for diagnosing T. cruzi exposure in dogs, but its performance substantially depends on the antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, and 8.4) and evaluated their potential for diagnosing T. cruzi exp...
Neutrophil properties in healthy and Leishmania infantum-naturally infected dogs.
Wardini, Amanda Brito; Silva, Lucia Helena Pinto da; Nadaes, Natalia Rocha; Nascimento, Michelle Tanny Cunha do; Roatt, Bruno MendesVisceral leishmaniasis is a chronic disease that afects humans and dogs as well. Dogs, the domestic reservoir of Leishmania, play a central role in the transmission of visceral leishmaniasis, the most severe form of this disease. Neutrophils are the most abundant leukocytes in blood and interact with the parasite after infection. Here, we evaluate the efector properties of neutrophils from healthy and naturally...
Peptide vaccines for leishmaniasis.
Brito, Rory Cristiane Fortes de; Cardoso, Jamille Mirelle de Oliveira; Reis, Levi Eduardo Soares; Vieira, João Filipe PereiraDue to an increase in the incidence of leishmaniases worldwide, the development of new strategies such as prophylactic vaccines to prevent infection and decrease the disease have become a high priority. Classic vaccines against leishmaniases were based on live or attenuated parasites or their subunits. Nevertheless, the use of whole parasite or their subunits for vaccine production has numerous disadvantages. T...
Effectiveness of deltamethrin-impregnated dog collars on the incidence of canin...
Vital, Wendel Coura; Leal, Gleisiane Gomes de Almeida; Marques, Luana Araújo; Pinheiro, Aimara da Costa; Carneiro, Mariângela; Reis, Alexandre BarbosaTo reduce morbidity and mortality caused by visceral leishmaniasis (VL), the Brazilian Visceral Leishmaniasis Control and Surveillance Program promotes the diagnosis and treatment of cases, vector control, euthanasia of seropositive dogs, and health education. Nevertheless, the effectiveness of these measures is questionable as they lead to little reduction in the transmission of the disease. Thus, the effectiv...
Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features...
Resende, Lucilene Aparecida; Soares, Rodrigo Dian de Oliveira Aguiar; Ker, Henrique Gama; Roatt, Bruno Mendes; Mendonça, Ludmila Zanandreis deFundação de Amparo a Pesquisa do Estado de Minas Gerais. Belo Horizonte, MG, Brazil; Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil/Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas/NUPEB Laboratório de Imunopatologia. Ouro Preto, MG, Brazil; Uni...
An assessment on epitope prediction methods for protozoa genomes.
Resende, Daniela de Melo; Rezende, Antonio Mauro; Oliveira, Nesley Jesus Daher de; Batista, Izabella Cristina Andrade; Oliveira, Rodrigo Corrêa deBackground: Epitope prediction using computational methods represents one of the most promising approaches to vaccine development. Reduction of time, cost, and the availability of completely sequenced genomes are key points and highly motivating regarding the use of reverse vaccinology. Parasites of genus Leishmania are widely spread and they are the etiologic agents of leishmaniasis. Currently, there is no eff...
A multicentric evaluation of the recombinant Leishmania infantum antigen-based ...
Fraga, Deborah Bittencourt Mothé; Silva, Edimilson Domingos da; Pacheco, Luciano Vasconcellos; Borja, Lairton Souza; Oliveira, Isaac Queiroz deBackground: Visceral leishmaniasis (VL) is a serious public health challenge in Brazil and dogs are considered to be the main urban reservoir of the causative agent. The culling of animals to control VL in some countries makes the accurate diagnosis of canine VL (CVL) essential. Recombinant antigens rLci1A and rLci2B were selected from a cDNA library of Leishmania infantum amastigotes due to their strong potent...
LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD...
Soares, Rodrigo Dian de Oliveira Aguiar; Roatt, Bruno Mendes; Ker, Henrique Gama; Moreira, Nádia das Dores; Mathias, Fernando Augusto SiqueiraBackground: The development of a protective vaccine against canine visceral leishmaniasis (CVL) is an alternative approach for interrupting the domestic cycle of Leishmania infantum. Given the importance of sand fly salivary proteins as potent immunogens obligatorily co-deposited during transmission of Leishmania parasites, their inclusion in an anti-Leishmania vaccine has been investigated in the last few deca...