4 documents found, page 1 of 1
Whole-genome sequencing as a tool for studying the microevolution of drug-resis...
Diniz, Jaciara; von Groll, Andrea; Unis, Gisela; Dalla-Costa, Elis Regina; Rosa Rossetti, Maria Lúcia; Vianna, Júlia Silveira; Ramos, Daniela FernandesTreatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Mycobacterium tuberculosis. We here in describe the microevolution of drug resistance in serial isolates from six previously treated patie...
Genomic-based surveillance reveals high ongoing transmission of multi-drug-resi...
Salvato, Richard Steiner; Reis, Ana Júlia; Schiefelbein, Sun Hee; Gómez, Michael Andrés Abril; Salvato, Stéphanie Steiner; Silva, Larissa Vitória daGenomic-based surveillance on the occurrence of drug resistance and its transmission dynamics has emerged as a powerful tool for the control of tuberculosis (TB). A whole-genome sequencing approach, phenotypic testing and clinical-epidemiological investigation were used to undertake a retrospective population-based study on drug-resistant (DR)-TB in Rio Grande do Sul, the largest state in Southern Brazil. The a...
Evaluation of antifungal, antimycobacterial and larvicide activity of the Duroi...
Reis, Ana Júlia; Lucas Carrion, Lillian; Rodrigues, Katiane; Montelli Fenalti, Juliana; Mata-Santos, Tais; Scaini, Carlos James; Martins, DaianeBachground and objective: The wide Amazonian biodiversity has been identified as a source of natural product candidates to various pharmacological activities, particularly in combating infectious diseases. Some species, such as the genus Duroia, belonging to the Rubiaceae family, has been characterized by the production of secondary metabolites with important biological properties, but there are few studies wit...
Tuberculosis: a study on health care reference
Possuelo, Lia Gonçalves; Reis, Ana Júlia; da Rosa, Anne Winck; Poli, Heloísa; Battisiti, Fabiane; Sartori, Maria Salette; Moraes, MariélliRationale and Objectives: The key element for the integration of health networks is an effective system of reference and counter reference, understood as a mechanism for mutual referral of patients between different levels of service complexity. Thus, the aim of this study was to identify and analyze the reference system for the referral of patients diagnosed with tuberculosis in the city of Santa Cruz do Sul, ...