25 documents found, page 1 of 3

The Polyvalent Day Hospital: Is there an excessive request of packed leucocyte-...

Background: The Polyvalent Day Hospital (PDH) allows the treatment of oncological diseases and chronic anemias on an outpatient basis, significantly improving the quality of life of these patients [1,2]. The lack of guidelines leads to variable transfusion practices between clinicians. Objective: The main aim of this study is to improve the management of resources used in the preparation of a transfusion unit. ...

Disruptions as opportunities for change in a community of practice on global ci...

Communities of practice (CoPs) enhance the work around global citizenship education (GCE), enriching ways of thinking and acting for social transformation. Through their shared expertise and collective actions, CoPs provide a platform for individuals to amplify their voices and raise collective awareness about social and environmental justice. Addressing this context, this article reports on a study that aimed ...

Practices in pelvic girdle pain in physiotherapy: tradução e adaptação cultural...

INTRODUÇÃO: A Dor da Cintura Pélvica (DCP) na gravidez é uma subcategoria da DCP, que difere na sua etiologia uma vez que está relacionada com a gravidez e associada a influências fisiológicas. A maioria das mulheres refere que a fisioterapia tem algum efeito na melhoria da sua sintomatologia dolorosa. Uma prática baseada na evidência ajuda a garantir que os pacientes recebem as melhores intervenções para a sua...

Myocardial RNA sequencing reveals new potential therapeutic targets in heart fa...

Heart failure with preserved ejection fraction (HFpEF) represents a global health challenge, with limited therapies proven to enhance patient outcomes. This makes the elucidation of disease mechanisms and the identification of novel potential therapeutic targets a priority. Here, we performed RNA sequencing on ventricular myocardial biopsies from patients with HFpEF, prospecting to discover distinctive transcri...

The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Br...

Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...

Generic XR game-based approach for industrial training

Over the years several Virtual Reality- (VR) and Augmented Reality- (AR) based learning environments have been proposed. However, they are usually built for a specified scenario and possess a very limited set of configurations. Moreover, the proposed solutions are designed solely to VR- or AR-based learning environments and only a few propose solutions that use both learning environments for training. The prese...

Global Education Digest 2022 [Portuguese]

No abstract available.

The role of MicroRNAs in proteostasis decline and protein aggregation during br...

Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in...

Unveiling the genome of Limtongozyma cylindracea

Redox Imbalance and Methylation Disturbances in Early Childhood Obesity

Obesity is increasing worldwide in prepubertal children, reducing the age of onset of associated comorbidities, including type 2 diabetes. Sulfur-containing amino acids, methionine, cysteine, and their derivatives play important roles in the transmethylation and transsulfuration pathways. Dysregulation of these pathways leads to alterations in the cellular methylation patterns and an imbalanced redox state. The...