2 documents found, page 1 of 1
Dermal extracellular matrix extracts for wound healing: a pleiotropic trigger
Reis, Daniel Pedro Pires Alves; Malta, Mariana Jorge Oliveira Cardoso Denis; Gasperini, Luca; Marques, A. P.INTRODUCTION: Extracellular matrix (ECM) role is defined by direct cell‐ECM interactions and biomechanics and also by its capacity to store biochemical cues that are vital in tissue's repair. With this in mind, an in‐house method was devised to obtain extracts comprised of structural ECM components (strECM) and enriched in soluble ECM‐derived factors (sECM). Herein we hypothesised that each ECM fraction may tri...
Monocyte-derived macrophages and dermal fibroblasts-derived ECM making small talk
Chaves, S.; Macedo, J.; Reis, Daniel Pedro Pires Alves; Silva, Lucília Pereira; Marques, A. P.[Excerpt] Introduction: 3D in vitro skin models allow studying molecular pathways that otherwise are only possible to explore using animal models. The incorporation of immune cells, such as macrophages, has been implemented to create immunocompetent analogues. Yet, the human biology representation in those models is limited, among other aspects, by the minimal extracellular matrix (ECM) mimicry[1]. In order to ...