Encontrados 6 documentos, a visualizar página 1 de 1
The role of functional connectivity in the treatment of depression: exploring n...
Reis, Joana Vanessa SantosA perturbação depressiva maior (PDM) é uma perturbação de humor prevalente e incapacitante. A depressão pode ter um impacto importante na capacidade que os pacientes têm em lidar com os eventos e atividades do dia-a-dia. Apesar da eficácia das opções de tratamento atuais, como antidepressivos ou psicoterapias baseadas em evidência, ainda existe uma importante fração de pacientes que experimentam longos episódio...
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and ...
Sardinha, Vanessa Alexandra Morais; Gomes, Sónia Isabel Nunes Guerra; Campos, Inês Caetano Costa; Tavares, Gabriela Pires; Martins, Manuella MendesAstrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotr...
AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not a...
Pinheiro, António Maria Restolho Mateus; Alves, N. D.; Patrício, Patrícia Carvalho; Santos, Ana Rita Machado dos; Campos, E. LoureiroHippocampal neurogenesis has been proposed to participate in a myriad of behavioral responses, both in basal states and in the context of neuropsychiatric disorders. Here, we identify activating protein 2γ 3 (AP2γ 3, also known as Tcfap2c), originally described to regulate the generation of neurons in the developing cortex, as a modulator of adult hippocampal glutamatergic neurogenesis in mice. Specifically, AP...
An Alpha and Theta Intensive and Short Neurofeedback Protocol for Healthy Aging...
Reis, Joana Vanessa Santos; Portugal, Ana Maria; Fernandes, Luís Filipe Silva; Afonso, Nuno; Pereira, Mariana; Sousa, Nuno; Dias, Nuno Sérgio MendesThe present study tested the effects of an intensive and short alpha and theta neurofeedback (NF) protocol in working memory (WM) performance in a healthy elder population and explored the effects of a multimodal approach, by supplementing NF with cognitive tasks. Participants were allocated to four groups: NF (N = 9); neurofeedback supplemented with cognitive training (NFCT) (N = 8); cognitive training (CT) (N...
Alpha and theta intensive neurofeedback protocol for age-related cognitive defi...
Reis, Joana Vanessa Santos; Portugal, A.; Pereira, Mariana R.; Dias, Nuno Sérgio MendesWith the growing life expectancy, the number of elderly people is increasing tremendously worldwide. The progressive decrease of synaptic plasticity and neuronal interconnectivity in the ageing brain, concomitant with alterations in key cognitive abilities such as working memory and attention, may be delayed, stopped or reversed by neurorehabilitation. Hence, current approaches used to modify cognitive capabili...
Cognitive intervention protocol for age-related memory impairments
Portugal, Ana Maria; Ferreira, Daniela Silva; Reis, Joana Vanessa Santos; Pinho, Francisco; Dias, Nuno Sérgio MendesWith the number of elderly people increasing tremendously worldwide, comes the need for effective methods to maintain or improve older adults' cognitive performance. Using continuous neurofeedback, through the use of EEG techniques, people can learn how to train and alter their brain electrical activity. A software platform that puts together the proposed rehabilitation methodology has been developed: a digital...