37 documents found, page 1 of 4
Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differen...
Simões, Rui F.; Oliveira, Paulo J.; Oliveira, Teresa Cunha; Pereira, Francisco B.With the increase in life expectancy and consequent aging of the world's population, the prevalence of many neurodegenerative diseases is increasing, without concomitant improvement in diagnostics and therapeutics. These diseases share neuropathological hallmarks, including mitochondrial dysfunction. In fact, as mitochondrial alterations appear prior to neuronal cell death at an early phase of a disease's onset...
Quantitative analysis of neuronal mitochondrial movement reveals patterns resul...
Simões, Rui F.; Pino, Rute; Soares, Maurício Moreira; Kovarova, Jaromira; Neuzil, Jiri; Travasso, Rui; Oliveira, Paulo J.; Cunha-Oliveira, TeresaAlterations in mitochondrial dynamics, including their intracellular trafficking, are common early manifestations of neuronal degeneration. However, current methodologies used to study mitochondrial trafficking events rely on parameters that are primarily altered in later stages of neurodegeneration. Our objective was to establish a reliable applied statistical analysis to detect early alterations in neuronal m...
Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxici...
Amorim, Ricardo; Simões, Inês C. M.; Veloso, Caroline; Carvalho, Adriana; Simões, Rui F.; Pereira, Francisco B.; Thiel, Theresa; Normann, AndreaNon-alcoholic steatohepatitis (NASH), one of the deleterious stages of non-alcoholic fatty liver disease, remains a significant cause of liver-related morbidity and mortality worldwide. In the current work, we used an exploratory data analysis to investigate time-dependent cellular and mitochondrial effects of different supra-physiological fatty acids (FA) overload strategies, in the presence or absence of fruc...
Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson...
Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Pereira, Francisco B.; Raimundo, Nuno Filipe Viegas das Neves; Oliveira, Paulo J.Parkinson's Disease (PD) is characterized by dopaminergic neurodegeneration in the substantia nigra. The exact mechanism by which dopaminergic neurodegeneration occurs is still unknown; however, mitochondrial dysfunction has long been implicated in PD pathogenesis. To investigate the sub-cellular events that lead to disease progression and to develop personalized interventions, non-neuronal cells which are coll...
Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthrac...
Pereira, Gonçalo Castro; Pereira, Susana P.; Pereira, Francisco B.; Lourenço, Nuno António Marques; Lumini, José A; Pereira, Cláudia V.; Bjork, James A.Doxorubicin (DOX) is an anticancer drug widely used to treat human and nonhuman tumors but the late and persistent cardio-toxicity reduces the therapeutic utility of the drug. The full mechanism(s) of DOX-induced acute, subchronic and delayed toxicity, which has a preponderant mitochondrial component, remains unclear; therefore, it is clinically relevant to identify early markers to identify patients who are pr...
Volatile fingerprinting differentiates diverse-aged craft beers
Coelho, Eduardo; Magalhães, J.; Pereira, Francisco B.; Silva, F.; Domingues, Lucília; Oliveira, José MariaBeer ageing on wood is a complex and difficult to control process involving several reactions and compounds. Difficulties in understanding the underlying phenomena often lead to empirical and unpredictable processes and heterogeneous products. This work resorts to volatile fingerprinting along with multivariate analysis as tools to differentiate and highlight differences in beers derived from diverse production...
Heuristics for multiobjective multiple sequence alignment
Abbasi, Maryam; Paquete, Luís; Pereira, Francisco B.Background: Aligning multiple sequences arises in many tasks in Bioinformatics. However, the alignments produced by the current software packages are highly dependent on the parameters setting, such as the relative importance of opening gaps with respect to the increase of similarity. Choosing only one parameter setting may provide an undesirable bias in further steps of the analysis and give too simplistic int...
Lignocellulosic bioethanol production with revalorization of low-cost agroindus...
Kelbert, Maikon; Romaní, Aloia; Coelho, Eduardo; Pereira, Francisco B.; Teixeira, J. A.; Domingues, LucíliaDuring the pretreatment of lignocellulosic biomass for second generation bioethanol production, fermentation inhibitors are released. To overcome this, the use of a robust industrial strain together with agro-industrial by-products as nutritional supplementation was proposed to increase ethanol productivity and yields. Two factorial experimental designs were carried out to optimize fermentation of hydrolysate f...
Optimization of low-cost nutritional supplementation for lignocellulosic ethano...
Romaní, Aloia; Kelbert, Maikon; Coelho, Eduardo; Pereira, Francisco B.; Teixeira, J. A.; Domingues, Lucília[Excerpt] Bioethanol from lignocellulosic materials (LCM), also called second generation bioethanol, is considered a promising alternative to first generation bioethanol. An efficient production process of lignocellulosic bioethanol involves an effective pretreatment of LCM to improve the accessibility of cellulose and thus enhance the enzymatic saccharification. One interesting approach is to use the whole slu...
Direct fit of spectroscopic data of diatomic molecules by using genetic algorit...
Prudente, Frederico Vasconcellos; Almeida, Marcos M.; Fellows, Carlos E.; Marques, Jorge M. C.; Pereira, Francisco B.; Prudente, Frederico VasconcellosTexto completo: acesso restrito. p. 1-8; Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-02-17T13:46:17Z No. of bitstreams: 1 Frederico V Prudente.pdf: 219657 bytes, checksum: 0b10e04f05f4964da1ff015a7fa9c60e (MD5); Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-02-21T18:49:43Z (GMT) No. of bitstreams: 1 Frederico V Prudente.pdf: 219657 bytes, checksum: 0b10e04f05f4...