11 documents found, page 1 of 2

Synthetic peptides elicit strong cellular immunity in Visceral Leishmaniasis na...

Reverse vaccinology or immunoinformatics is a computational methodology which integrates data from in silico epitope prediction, associated to other important information as, for example, the predicted subcellular location of the proteins used in the design of the context of vaccine development. This approach has the potential to search for new targets for vaccine development in the predicted proteome of pathog...

Peptide vaccines for leishmaniasis.

Due to an increase in the incidence of leishmaniases worldwide, the development of new strategies such as prophylactic vaccines to prevent infection and decrease the disease have become a high priority. Classic vaccines against leishmaniases were based on live or attenuated parasites or their subunits. Nevertheless, the use of whole parasite or their subunits for vaccine production has numerous disadvantages. T...

Nanofarmacologia na leishmaniose visceral empregando uma mistura de lipossomas ...

Programa de Pós-Graduação em Ciências Farmacêuticas. CIPHARMA, Escola de Farmácia, Universidade Federal de Ouro Preto.; Os antimoniais pentavalentes são fármacos de 1ª escolha no tratamento das leishmanioses no Brasil. Em virtude dos vários efeitos colaterais do tratamento, a associação do fármaco em lipossomas poderia aumentar a adesão e a eficácia terapêutica. Sendo assim, o objetivo deste estudo foi avaliar ...

A vaccine therapy for canine visceral leishmaniasis promoted significant improv...

Herein, we evaluated the treatment strategy employing a therapeutic heterologous vaccine composed of antigens of Leishmania braziliensis associated with MPL adjuvant (LBMPL vaccine) for visceral leishmaniasis (VL) in symptomatic dogs naturally infected by Leishmania infantum. Sixteen dogs received immunotherapy with MPL adjuvant (n = 6) or with a vaccine composed of antigens of L. braziliensis associated with M...

Medicamentos anti-hipertensivos utilizados na área rural de Ouro Preto, MG.

Pharmacokinetic and tissue distribution of benznidazole after oral administrati...

Specific chemotherapy using benznidazole (BNZ) for Chagas disease during the chronic stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been used to treat Chagas disease since the 1970s, few studies about the biodistribution of this drug exist. In this study, BNZ tissue biodistribution in a murine model and its pharmacokinetic profile in plasma were monitored. A bioanalytical...

Dogs infected with the blood trypomastigote form of Trypanosomacruzi display an...

The recent increase in immigration of people from areas endemic for Chagas disease (Trypanosoma cruzi)to the United States and Europe has raised concerns about the transmission via blood transfusion andorgan transplants in these countries. Infection by these pathways occurs through blood trypomastigotes(BT), and these forms of T. cruzi are completely distinct of metacyclic trypomastigotes (MT), releasedby triat...

Molecular diagnosis of canine visceral leishmaniasis : a comparative study of t...

Polymerase chain reaction (PCR) and its variations represent highly sensitive and specificmethods for Leishmania DNA detection and subsequent canine visceral leishmaniasis (CVL)diagnosis. The aim of this work was to compare three different molecular diagnosis tech-niques (conventional PCR [cPCR], seminested PCR [snPCR], and quantitative PCR [qPCR])in samples of skin and spleen from 60 seropositive dogs by immun...

Clinical forms of canine visceral Leishmaniasis in naturally Leishmania infantu...

Hematological analysis has limited applications for disease diagnosis in Leishmania infantum–infected dogs, but it can be very important in evaluating the clinical forms of the disease and in understanding the evolution of canine visceral leishmaniasis (CVL) pathogenesis. Recently, we demonstrated that alterations in leucopoiesis and erythropoiesis are related to clinical status and bone marrow parasite density...

Canine visceral leishmaniasis : incidence and risk factors for infection in a c...

Zoonotic visceral leishmaniasis in Brazil is caused by Leishmania infantum parasites andis transmitted by sand flies of the Phlebotominae family. Dogs are the main urban reser-voirs and represent the major source of contagion for the vectors. Studies have shown thatmost infected dogs are polymerase chain reaction-positive months before seroconversion.Herein, we describe a cohort study designed to identify the i...