6 documents found, page 1 of 1
Electrospun polycaprolactone membranes functionalized with nanochitin for enhan...
Costa, Sofia Maria Soares; Mattos, Bruno D.; Calhelha, Ricardo C.; Zhu, Ya; Lima, Eurico; Reis, Lucinda V.; Rojas, Orlando J.; Fangueiro, RaúlThe encapsulation of photosensitizers (PSs) in electrospun membranes has emerged as a promising approach in photodynamic therapy (PDT) on tumor sites, overcoming the drawbacks associated with systemic administration. In this work, localized implants for cancer treatment using PDT were developed by incorporating EL-2 squaraine into poly(ɛ-caprolactone) (PCL) electrospun microfibers. The latter were coated with c...
Evaluation of antifungal activity and potential application as fluorescent prob...
Gomes, Vanessa S. D.; Ferreira, João C. C.; Boto, Renato E.; Almeida, Paulo; Fernandes, José R.; Sousa, Maria João; Reis, Lucinda V.The antifungal performance and the possible use as fluorescent probes of a series of squarylium dyes derived from indolenine and benzo[e]indole previously synthesized was evaluated. Some photophysical properties were performed in ethanol and phosphate buffer, and the type of aggregates form in phosphate buffer was analyzed. Using the 1,3-diphenylisobenzofuran assay, a qualitative assessment of the capacity of d...
Squaraine dyes derived from indolenine and benzo[e]indole as potential fluoresc...
Gomes, Vanessa Sofia Dias; Ferreira, João C. C.; Boto, Renato E. F.; Almeida, Paulo; Fernandes, Jose R.; Sousa, Maria João; Gonçalves, M. Sameiro T.Four squaraine dyes derived from 2,3,3-trimethylindolenine and 1,1,2-trimethyl-1H-benzo[e]indole with different combinations of barbituric groups attach to the central ring, having ester groups and alkyl chains in the nitrogen atoms of heterocyclic rings were synthesized. These dyes were fully characterized and their photophysical behavior was studied in ethanol and phosphate-buffered saline solution. Absorptio...
Squaraine dyes as serum albumins probes: synthesis, photophysical experiments a...
Gomes, Vanessa Sofia Dias; Boto, Renato E. F.; Almeida, Paulo; Coutinho, Paulo J. G.; Pereira, Mário R.; Gonçalves, M. Sameiro T.; Reis, Lucinda V.Three barbiturate squaraine dyes derived from indolenine or benzothiazole, with different barbituric acid derivatives were prepared, characterized and photophysically evaluated by standard spectroscopic methods. As expectable for squaraines, these dyes showed narrow and intense absorption and emission bands in the Vis/NIR region. The interaction of synthesized dyes with bovine and human serum albumins (BSA and ...
Quinoline- and benzoselenazole-derived unsymmetrical squaraine cyanine dyes: de...
Lima, Eurico; Boto, Renato E.; Ferreira, Diana P.; Fernandes, José R.; Almeida, Paulo; Ferreira, Luis F. V.; Souto, Eliana B.; Silva, Amélia M.Photodynamic therapy is an innovative treatment approach broadly directed towards oncological diseases. Its applicability and efficiency are closely related to the interaction of three main components, namely a photosensitizer, light and molecular triplet oxygen, which should drive cell death. Recently, several studies have demonstrated that squaraine cyanine dyes have a set of photophysical and photochemical p...
Red and near-infrared absorbing dicyanomethylene squaraine cyanine dyes: photop...
Martins, Tiago D.; Lima, Eurico; Boto, Renato E.; Ferreira, Diana Sara Pereira; Fernandes, José R.; Almeida, Paulo; Ferreira, Luis F. V.Photodynamic therapy is a medical modality developed for the treatment of several diseases of oncological and non-oncological etiology that requires the presence of a photosensitizer, light and molecular oxygen, which combined will trigger physicochemical reactions responsible for reactive oxygen species production. Given the scarcity of photosensitizers that exhibit desirable characteristics for its potential ...