28 documents found, page 1 of 3
EIR para a fase de projeto de uma obra privada
Granja, J.; Silva de Oliveira, A.; Pinto, D.; Lima, F.; Silva, H.; Rodrigues, I.; Fonseca, J.; Neves Adelino, J.; João Poças Martins; Lino, J. C.
WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Gonçalves, C.; Vieira de Castro, J.; Pojo, M.; Martins, E.; Queirós, S.; Chautard, E.; Taipa, Ricardo; Pires, M.; Pinto, A.; Pardal, F.; Custódia, C.Glioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated in GBM. WNT6 levels were...
Under-vaccinated groups in Europe and their beliefs, attitudes and reasons for ...
Fournet, N.; Mollema, L.; Ruijs, W. L.; Harmsen, .I A.; Keck, F.; Durand, Jean-Yves; Cunha, Manuela Ivone P. da; Wamsiedel, M.; Reis, R.; French, J.Background: Despite effective national immunisation programmes in Europe, some groups remain incompletely or un-vaccinated (‘under-vaccinated’), with underserved minorities and certain religious/ideological groups repeatedly being involved in outbreaks of vaccine preventable diseases (VPD). Gaining insight into factors regarding acceptance of vaccination of ‘under-vaccinated groups’ (UVGs) might give opportunit...
BIM (Building Information Modelling) as a prevention tool in the design and con...
Tender, M.; Couto, J. Pedro; Lopes, C.; Cunha, T.; Reis, R.BIM tools have been gaining relevance in the development and management of projects. That is not yet the case when it comes to the Health and Safety Plan (HSP) and the Technical File (TF). The current way of managing prevention often results in a long list of procedures that are hard to understand by those who should be implementing them. This whole scenario creates an environment prone to the downgrading of th...
Expression of BRCA2 protein in prostatectomy and its correlation with needle co...
Reis, R.
Brachyury as a potential modulator of androgen receptor activity and a key play...
Pinto, F.ilipe; Pértega-Gomes, N.; Vizcaíno, J.; Andrade, R.; Cárcano, F.; Reis, R.Prostate cancer (PCa) is the most commonly diagnosed neoplasm and the second leading cause of cancer-related deaths in men. Acquisition of resistance to conventional therapy is a major problem for PCa patient management. Several mechanisms have been described to promote therapy resistance in PCa, such as androgen receptor (AR) activation, epithelial-to-mesenchymal transition (EMT), acquisition of stem cell prop...
Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenot...
Miranda-Gonçalves, V.; Granja, S.; Martinho, O.; Honavar, M.; Pojo, M.; Costa, B.; Melo-Pires, M.; Pinheiro, C.; Cordeiro, M.; Bebiano, G.; Costa, P.BACKGROUND: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment through monocarboxylate transporters (MCTs). While hypoxia-mediated regulation of MCT4 has been characterized, the r...
Land use and land cover changes in Zêzere watershed (Portugal): water quality i...
Meneses, Bruno; Reis, R.; Vale, M. J.; Saraiva, R.To understand the relations between land use allocation and water quality preservation within a watershed is essential to assure sustainable development. The land use and land cover (LUC) within Zêzere River watershed registered relevant changes in the last decades. These land use and land cover changes (LUCCs) have impacts in water quality, mainly in surface water degradation caused by surface runoff from arti...
Coastal risk forecast system
Sabino, A.; Rodrigues, A.; Poseiro, P.; Reis, M. T.; Fortes, C. J. E. M.; Reis, R.Runnup and overtopping are the two main sea wave originated events that threat coastal structures. These events may cause destruction of property and the environment, and endanger people. To build early warning forecast systems, we must take into account the consequence and risk characterization of the events in the affected area, and understand how these two types of spatial information integrate with sensor d...
Ferramenta de apoio à gestão costeira e portuária: o sistema HIDRALERTA
Fortes, C. J. E. M.; Reis, M. T.; Poseiro, P.; Santos, J. A.; Garcia, T.; Capitão, R.; Pinheiro, L.; Reis, R.; Craveiro, J.; Lourenço, I.; Lopes, P.Nesta comunicação, descreve-se o sistema HIDRALERTA (sistema de previsão e alerta de inundações em zonas costeiras e portuárias), sistema em ambiente SIG que tem como ideia-base a utilização de previsões da agitação marítima (a 180 horas) para calcular os seus efeitos na costa, nomeadamente em termos de galgamentos e inundações. Dos desenvolvimentos mais recentes ou em curso destacam-se: a construção de mapas d...