3 documents found, page 1 of 1
The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamic...
Acreman, Samuel; Ma, Jinfang; Denwood, Geoffrey; Gao, Rui; Tarasov, Andrei; Rorsman, Patrik; Zhang, QuanGlucagon is secreted by pancreatic α-cells to counteract hypoglycaemia. How glucose regulates glucagon secretion remains unclear. Here, using mouse islets, we studied the role of transmembrane and endoplasmic reticulum (ER) Ca2+ on intrinsic α-cell glucagon secretion. Blocking isradipine-sensitive L-type voltage-gated Ca2+ (Cav) channels abolished α-cell electrical activity but had little impact on its cytosoli...
α-cell electrophysiology and the regulation of glucagon secretion
Gao, Rui; Acreman, Samuel; Ma, Jinfang; Abdulkader, Fernando; Wendt, Anna; Zhang, QuanGlucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic α-cells, are electrically excitable cells and use electrical activity to couple its hormone secretion to changes in ambient glucose levels. Exactly how glucose regul...
Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA d...
Gao, Rui; Liu, Yongping; Fernandes, Anabela Silva; Fang, Xiang; Paulucci- Holthauzen, Adriana; Chatterjee, Arpita; Zhang, Hang L.; Matsuura, TohruSpinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an untreatable autosomal dominant neurodegenerative disease, and the most common such inherited ataxia worldwide. The mutation in SCA3 is the expansion of a polymorphic CAG tri-nucleotide repeat sequence in the C-terminal coding region of the ATXN3 gene at chromosomal locus 14q32.1. The mutant ATXN3 protein encoding expanded gl...