33 documents found, page 1 of 4
The characterization and cytotoxic evaluation of chondrosia reniformis collagen...
Rocha, Miguel S.; Marques, Catarina F.; Carvalho, Ana C.; Martins, Eva; Ereskovsky, Alexander; Reis, Rui L.; Silva, Tiago H.Chondrosia reniformis is a collagen-rich marine sponge that is considered a sustainable and viable option for producing an alternative to mammalian-origin collagens. However, there is a lack of knowledge regarding the properties of collagen isolated from different sponge parts, namely the outer region, or cortex, (ectosome) and the inner region (choanosome), and how it affects the development of biomaterials. I...
Marine gelatin-methacryloyl-based hydrogels as cell templates for cartilage tis...
Machado, Inês; Marques, Catarina F.; Martins, Eva; Alves, Ana L.; Reis, Rui L.; Silva, Tiago H.Marine-origin gelatin has been increasingly used as a safe alternative to bovine and porcine ones due to their structural similarity, avoiding the health-related problems and sociocultural concerns associated with using mammalian-origin materials. Another benefit of marine-origin gelatin is that it can be produced from fish processing-products enabling high production at low cost. Recent studies have demonstrat...
In vivo skin hydrating efficacy of fish collagen from greenland halibut as a hi...
Martins, Eva; Reis, Rui L.; Silva, Tiago H.The industrial processing of fish for food purposes also generates a considerable number of by-products such as viscera, bones, scales, and skin. From a value-added perspective, fish by-products can act also as raw materials, especially because of their collagen content (particularly in fish skin). Interestingly, the potential of marine collagen for cosmetic applications is enormous and, remarkably, the extract...
Functional recovery of injured cavernous nerves achieved through endogenous ner...
Casanova, Marta R.; Mota, Paulo; Vala, Helena; Nóbrega, Carmen; Morais, Alain da Silva; Silva, Catarina S.; Barros, Alexandre A.; Reis, Rui L.Radical prostatectomy is a highly successful treatment for prostate cancer, among the most prevalent manifestations of the illness. Damage of the cavernous nerve (CN) during prostatectomy is the main cause of postoperative erectile dysfunction (ED). In this study, the capability of a personalized bioactive fibrous membrane to regenerate injured CN was investigated. The fibrous membrane bioactivity is conferred ...
Hyaluronic acid hydrogels incorporating platelet lysate enhance human pulp cell...
Almeida, Leopoldina D. F.; Babo, Pedro S.; Silva, Cristiana R.; Rodrigues, Márcia T.; Hebling, Josimeri; Reis, Rui L.; Gomes, Manuela E.Made available in DSpace on 2022-04-29T08:45:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-01; The restoration of dentine-pulp complex remains a challenge for dentists; nonetheless, it has been poorly addressed. An ideal system should modulate the host response, as well as enable the recruitment, proliferation and differentiation of relevant progenitor cells. Herein was proposed a photocrosslinka...
Sardine roe as a source of lipids to produce liposomes
Guedes, Marta; Costa-Pinto, Ana Rita; Gonçalves, Virgínia; Moreira-Silva, Joana; Tiritan, Maria; Reis, Rui L.; Ferreira, Helena; Neves, Nuno M.Sea-derived materials have promising applications in the medical, pharmaceutical, and biotechnological fields. Fish roe, for example, is a highly nutritional product, presenting diverse beneficial effects on human health. Therefore, this work explored extracts of sardine (Sardina pilchardus) roe, due to the well-known health benefits of this fish, to produce novel and promising delivery systems. After morpholog...
Convection patterns gradients of non-living and living micro-entities in hydrogels
Canadas, Raphaël F.; Patricio, Pedro; Brancato, Virginia; Gasperini, Luca; Caballero, David; Pires, Ricardo A.; Costa, João; Pereira, Hélder; Yong, PingInducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the c...
Enzymatically cross-linked silk fibroin-based hierarchical scaffolds for osteoc...
Ribeiro, Viviana P.; Pina, Sandra; Costa, João B.; Cengiz, Ibrahim Fatih; García-Fernández, Luis; Fernández-Gutiérrez, Maria del Mar; Paiva, Olga C.Osteochondral (OC) regeneration faces several limitations in orthopedic surgery, owing to the complexity of the OC tissue that simultaneously entails the restoration of articular cartilage and subchondral bone diseases. In this study, novel biofunctional hierarchical scaffolds composed of a horseradish peroxidase (HRP)-cross-linked silk fibroin (SF) cartilage-like layer (HRP-SF layer) fully integrated into a HR...
Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration
Geão, Catarina; Costa-Pinto, Ana R.; Cunha-Reis, Cassilda; Ribeiro, Viviana P.; Vieira, Sílvia; Oliveira, Joaquim M.; Reis, Rui L.; Oliveira, A. L.Guided tissue regeneration (GTR) is a surgical procedure applied in the reconstruction of periodontal defects, where an occlusive membrane is used to prevent the fast-growing connective tissue from migrating into the defect. In this work, silk fibroin (SF) membranes were developed for periodontal guided tissue regeneration. Solutions of SF with glycerol (GLY) or polyvinyl alcohol (PVA) where prepared at several...
Show your beaks and we tell you what you eat: different ecology in sympatric An...
Matias, Ricardo S.; Gregory, Susan; Ceia, Filipe R.; Baeta, Alexandra; Seco, José; Rocha, Miguel S.; Fernandes, Emanuel M.; Reis, Rui L.Sympatry can lead to higher competition under climate change and other environmental pressures, including in South Georgia, Antarctica, where the two most common octopod species, Adelieledone polymorpha and Pareledone turqueti, occur side by side. Since cephalopods are typically elusive animals, the ecology of both species is poorly known. As beaks of cephalopods are recurrently found in top predator's stomachs...