21 documents found, page 1 of 3
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chem...
De Marchi, Pedro; Melendez, Matias E.; Laus, Ana C.; Kuhlmann, Pamela A.; de Carvalho, Ana Carolina; Arantes, Lidia Maria R.B.; Evangelista, Adriane F.Made available in DSpace on 2022-04-28T19:27:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background: Induction chemotherapy in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) patients is potentially associated to serious adverse events. Biomarkers associated with toxicity could tailor its indication. This...
Deregulated micrornas are associated with patient survival and predicted to tar...
Souza, Cristiano P. [UNESP]; Cinegaglia, Naiara C. [UNESP]; Felix, Tainara F. [UNESP]; Evangelista, Adriane F.; Oliveira, Rogério A. [UNESP]Made available in DSpace on 2021-06-25T10:34:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01; Financiadora de Estudos e Projetos; (1) Background: Although the advances in diagnostic and treatment strategies, lung cancer remains the leading cause of cancer-related deaths, worldwide, with survival rates as low as 16% in developed countries. Low survival rates are mainly due to late diagnosis and t...
Evaluation of the prognostic potential of EGFL7 in pilocytic astrocytomas
Brunhara, Bruno B.; Becker, Aline P.; Neder, Luciano; Gonçalves, Paola G. [UNESP]; de Oliveira, Cristiane [UNESP]; Clara, Carlos A.; Reis, Rui M.Made available in DSpace on 2021-06-25T10:45:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Pilocytic astrocytoma (PA) is the most frequent solid neoplasm in childhood. It has a good 5-year overall survival (90% in childhood and 52% in adults). However, up to 20%...
Nose-to-brain co-delivery of drugs for glioblastoma treatment using nanostructu...
Ferreira, Natália N. [UNESP]; de Oliveira Junior, Edilson; Granja, Sara; Boni, Fernanda I. [UNESP]; Ferreira, Leonardo M.B. [UNESP]Made available in DSpace on 2021-06-25T10:31:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-15; Mutations on the epidermal growth factor receptor (EGFR), induction of angiogenesis, and reprogramming cellular energetics are all biological features acquired by tumor cells during tumor development, and also known as the hallmarks of cancer. Targeted therapies that combine drugs that are capable of ac...
MCT1 is a new prognostic biomarker and its therapeutic inhibition boosts respon...
Miranda-Gonçalves, Vera; Gonçalves, Celine Saraiva; Granja, Sara Costa; Castro, Joana Isabel Martins Cosme Vieira; Reis, Rui M.; Costa, Bruno M.<i>Background:</i> Glioblastomas (GBMs) present remarkable metabolism reprograming, in which many cells display the “Warburg effect”, with the production of high levels of lactate that are extruded to the tumour microenvironment by monocarboxylate transporters (MCTs). We described previously that MCT1 is up-regulated in human GBM samples, and MCT1 inhibition decreases glioma cell viability and aggressiveness. I...
Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gast...
Torres de Oliveira, Antonio Talvane; Reis, Rui M.; Afonso, Julieta; Martinho, Olga; Matos, Delcio; Carvalho, Andre Lopes; Vazquez, Vinicius LimaMade available in DSpace on 2020-12-10T16:35:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-01; Portuguese Science and Technology Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tu...
Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platfo...
Ferreira, Natália N. [UNESP]; Granja, Sara; Boni, Fernanda I. [UNESP]; Prezotti, Fabíola G. [UNESP]; Ferreira, Leonardo M. B. [UNESP]Made available in DSpace on 2020-12-12T01:31:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Nose-to-brain delivery is a promising approach to target drugs into the brain, avoiding the blood-brain barrier and other drawbacks related to systemic absorption, and enabling an effective and safer treatment of diseases such as glioblastoma (GBM). Innovative materials and technologies that improve res...
A novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinn...
Ferreira, Natália N. [UNESP]; Granja, Sara; Boni, Fernanda Isadora [UNESP]; Ferreira, Leonardo M. B. [UNESP]; Reis, Rui M.; Baltazar, FátimaMade available in DSpace on 2020-12-12T01:12:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação para a Ciência e a Tecnologia; Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives f...
A novel molecular link between HOXA9 and WNT6 in glioblastoma identifies a subg...
Gonçalves, Céline S.; Xavier‐Magalhães, Ana; Martins, Eduarda P.; Pinto, Afonso A.; Pires, Manuel; Pinheiro, Célia; Reis, Rui M.; Sousa, NunoDespite much effort to improve treatments, patients with malignant glioma still present a very poor prognosis that has not changed significantly in the last decades. In this context, it is crucial to better understand glioma pathogenesis to identify new molecular prognostic subgroups and therapeutic targets. WNT6 was recently identified as a new oncogenic molecule in glioblastoma (GBM), with prognostic value in...
The T-box transcription factor brachyury behaves as a tumor suppressor in gliomas
Pinto, Filipe; Costa, Angela M.; Santos, Gisele C.; Matsushita, Marcus M.; Costa, Sandra; Silva, Viviane A. O.; Miranda-Goncalves, VeraThe oncogene brachyury (TBXT) is a T-box transcription factor that is overexpressed in multiple solid tumors and is associated with tumor aggressiveness and poor patient prognosis. Gliomas comprise the most common and aggressive group of brain tumors, and at the present time the functional and clinical impact of brachyury expression has not been investigated previously in these neoplasms. Brachyury expression (...