6 documents found, page 1 of 1
Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
Nóbrega, Otávio T.; Morais-Junior, Gilberto S.; Viana, Nayara I.; Reis, Sabrina T.; Perez, Diego I. V.; Freitas, Wladimir M.; Sposito, Andrei C.Made available in DSpace on 2022-04-28T19:28:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; The human aging is marked by several body changes, including in bone mineral density (BMD). Research shows that microRNAs are important modulators of bone metabolism. The present research aims to analyze the whole blood concentration of 10 selected microRNAs (miRs) and their association with absolute an...
Prima-1 induces apoptosis in bladder cancer cell lines by activating p53
Piantino, Camila B.; Reis, Sabrina T.; Viana, Nayara I.; Silva, Iran A.; Morais, Denis R.; Antunes, Alberto A.; Dip, Nelson; Srougi, MiguelOBJECTIVES: Bladder cancer represents 3% of all carcinomas in the Brazilian population and ranks second in incidence among urological tumors, after prostate cancer. The loss of p53 function is the main genetic alteration related to the development of high-grade muscle-invasive disease. Prima-1 is a small molecule that restores tumor suppressor function to mutant p53 and induces cancer cell death in various canc...
The role of micro RNAs let7c, 100 and 218 expression and their target RAS, C-MY...
Reis, Sabrina T.; Timoszczuk, Luciana S.; Pontes-Junior, José; Viana, Nayara; Silva, Iran A.; Dip, Nelson; Srougi, Miguel; Leite, Katia R.M.OBJECTIVE: The aim of this study is to verify the expression of proteins that are controlled by miR-let7c, 100 and 218 using immunohistochemistry in tissue microarray representative of localized and metastasized the lymph nodes and bone prostate cancer. METHODS: To verify the expression of proteins that are controlled by miR-let7c (C-MYC, BUB1, RAS) 100 (SMARCA5, RB) and 218 (LAMB3) and cell proliferation (Ki-6...
MicroRNA 100: a context dependent miRNA in prostate cancer
Leite, Katia R.M.; Morais, Denis R.; Reis, Sabrina T.; Viana, Nayara; Moura, Caio; Florez, Manuel Garcia; Silva, Iran A.; Dip, Nelson; Srougi, MiguelOBJECTIVE: MicroRNAs are noncoding RNA molecules involved in the development and progression of tumors. We have found that miRNA-100 is underexpressed in metastatic prostate cancer compared to localized disease. Conversely higher levels of miR-100 are related to biochemical recurrence after surgery. This suggests that miR-100 may be a context-dependent miRNA, acting as oncogene or tumor suppressor miRNA. Our ai...
Standard surgical treatment for benign prostatic hyperplasia is safe for patien...
Marmiroli, Rafael; Antunes, Alberto A.; Reis, Sabrina T.; Nakano, Elcio; Srougi, MiguelOBJECTIVES: In this study, we aimed to determine the complications of standard surgical treatments among patients over 75 years in a high-volume urologic center. METHODS: We analyzed 100 consecutive patients older than 75 years who had undergone transurethral prostatic resection of the prostate or open prostatectomy for treatment of benign prostatic hyperplasia from January 2008 to March 2010. We analyzed patie...
Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic ...
Watanabe, Fábio T.; Chade, Daher C.; Reis, Sabrina T.; Piantino, Camila; Dall’ Oglio, Marcos Francisco; Srougi, Miguel; Leite, Katia R. M.OBJECTIVE: Cigarette smoking is the main risk factor for bladder cancer development. Among the mediators of this effect of smoking is nuclear factor-kappa B. Curcumin suppresses cellular transformation by downregulating the activity of nuclear factor-kappa B. Prima-1 is a compound that induces apoptosis in human tumor cells, restoring the function of mutant p53. Our study aimed to evaluate the effects of curcum...