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Ecotoxicity of the lipid-lowering drug bezafibrate on the bioenergetics and lip...

Duarte, Bernardo; Prata, Diogo; Matos, Ana Rita; Cabrita, Maria Teresa; Caçador, Isabel; Marques, J. C.; Cabral, Henrique; Reis Santos, Patrick

Pharmaceutical residues impose a new and emerging threat to the marine environment and its biota. In most countries, ecotoxicity tests are not required for all pharmaceutical residues classes and, even when mandatory, these tests are not performed using marine primary producers such as diatoms. These microalgae are among the most abundant class of primary producers in the marine realm and key players in the mar...


Screening of human and veterinary pharmaceuticals in estuarine waters: A baseli...

Reis Santos, Patrick; Pais, Miguel Pessanha; Duarte, Bernardo; Caçador, Isabel; Freitas, Andreia; Vila Pouca, Ana S.; Barbosa, Jorge; Leston, Sara

We investigated the presence of 66 human and veterinary pharmaceuticals from seven therapeutic groups in surface waters of the Tejo estuary. Collection sites covered the entire estuary and included areas near main river inflows and wastewater treatment outfalls, traversing urban, agriculture, aquaculture, and nature reserve areas. Detection of pharmaceuticals was performed via UHPLC-TOF-MS. Pharmaceuticals were...


Reconciling differences in natural tags to infer demographic and genetic connec...

Reis Santos, Patrick; Tanner, Susanne; Aboim, Maria Ana; P Vasconcelos, Rita; Laroche, Jean; Charrier, Grégory; Pérez, Montse; Presa, Pablo

Processes regulating population connectivity are complex, ranging from extrinsic environmental factors to intrinsic individual based features, and are a major force shaping the persistence of fish species and population responses to harvesting and environmental change. Here we developed an integrated assessment of demographic and genetic connectivity of European flounder Platichthys flesus in the northeast Atla...


Extrinsic and intrinsic factors shape the ability of using otolith chemistry to...

Reis Santos, Patrick; P Vasconcelos, Rita; Tanner, Susanne; Fonseca, Vanessa; Cabral, Henrique; Gillanders, Bronwyn M.

Reconstructing habitat use and environmental histories of fish via otolith chemistry relies on linking otolith chemical composition to the surrounding environment, as well as disentangling the consequences of ontogenetic or physiological effects that may mask environmental signals. We used multiple linear and linear mixed models to analyse the importance of environmental (temperature, salinity, water chemistry)...


Biomarker responses to environmental contamination in estuaries: A comparative ...

Duarte, Irina; Reis Santos, Patrick; França, Susana; Cabral, Henrique; Fonseca, Vanessa

Estuaries are highly productive ecosystems subjected to numerous anthropogenic pressures with consequent environmental quality degradation. In this study, multiple biomarker responses [superoxide dismutase (SOD), catalase (CAT), ethoxyresorufin O-deethylase (EROD) and glutathione S-transferase (GST) activities, as well as lipid peroxidation (LPO) and DNA damage (DNAd)] were determined in two fish (Dicentrarchus...


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