3 documents found, page 1 of 1
Cardiac molecular remodeling by anticancer drugs: Doxorubicin affects more meta...
Brandão, Sofia Reis; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Rocha, Hugo; Carvalho, Félix; Ferreira, Rita; Costa, Vera MarisaDoxorubicin (DOX) and mitoxantrone (MTX) are classical chemotherapeutic agents used in cancer that induce similar clinical cardiotoxic effects, although it is not clear if they share similar underlying molecular mechanisms. We aimed to assess the effects of DOX and MTX on the cardiac remodeling, focusing mainly on metabolism and autophagy. Adult male CD-1 mice received pharmacologically relevant cumulative dose...
Molecular alterations underlying Doxorubicin’s Chronic Cardiotoxicity in a mous...
Reis Brandão, Sofia; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa
Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone...
Brandão, Sofia Reis; Reis-Mendes, Ana; Domingues, Pedro; Duarte, José Alberto; Bastos, Maria Lourdes; Carvalho, Félix; Ferreira, RitaCurrent cancer therapies are successfully increasing the lifespan of cancer patients. Nevertheless, cardiotoxicity is a serious chemotherapy-induced adverse side effect. Doxorubicin (DOX) and mitoxantrone (MTX) are cardiotoxic anticancer agents, whose toxicological mechanisms are still to be identified. This study focused on DOX and MTX's cardiac mitochondrial damage and their molecular mechanisms. As a hypothe...