5 documents found, page 1 of 1
Matrix metalloproteinases in focus: an exploratory epidemiological study in a N...
Foresti, Manon; Garcia, Catarina; Gonçalves, Maria; Relvas, Marta; Viana da Costa, AlexandraBackground: Matrix metalloproteinases (MMPs) are zinc-dependent enzymes that regulate extracellular matrix degradation and remodelling. Among them, MMP-8 and MMP-9 are key mediators of inflammation, tissue remodelling, and wound healing. They have been implicated in both type 1 diabetes mellitus (T1DM) and periodontal disease (PD) [1]. The literature indicates a bidirectional association between T1DM and PD: ch...
In the network of periodontitis immunomediators
Viana da Costa, Alexandra; Mendes-Frias, Ana; Gonçalves, Maria; Salazar, Filomena; Silvestre, Ricardo; Relvas, MartaBackground: Severe periodontitis is considered the sixth most prevalent disease worldwide [1]. It is a chronic inflammatory condition affecting the tooth-supporting structures due to genetic, environmental, and microbial factors [2]. The host immune response partially contributes to the magnitude of the inflammatory process. Furthermore, this process involves a diversity of immunomediators that initiate and sus...
Analysis of salivary levels of IL-1β, IL17A, OPG and RANK-L in periodontitis us...
Relvas, Marta; Silvestre, Ricardo Jorge Leal; Gonçalves, Maria; Cabral, Cristina; Frias, Ana Isabel Mendes; Monteiro, Luís; Viana da Costa, AlexandraPeriodontitis is a chronic disease with a high overall prevalence. It involves a complex interplay between the immune-inflammatory pathways and biofilm changes, leading to periodontal attachment loss. The aims of this study were (i) to assess whether the salivary IL-1β, IL-17A, RANK-L and OPG levels have the potential to discriminate between the mild and severe periodontitis conditions; and (ii) to enable diagn...
In vitro study of preload loss in different implant abutment connection designs
Vinhas, Ana Sofia; Aroso, Carlos; Salazar, Filomena; Relvas, Marta; Braga, A. C.; Ríos-Carrasco, Blanca; Gil, Javier; Rios-Santos, José VicenteThe stability and integrity of the abutment-implant connection, by means of a screw, is fallible from the moment the prosthetic elements are joined and is dependent on the applied preload, wear of the components and function. One of the main causes of screw loosening is the loss of preload. The loosening of the screw-abutment can cause complications such as screw fracture, marginal gap, peri-implantitis, bacter...
Study of prevalence, severity and risk factors of periodontal disease in a Port...
Relvas, Marta; López-Jarana, Paula; Monteiro, Luis; Pacheco, José Júlio; Braga, A. C.; Salazar, FilomenaPeriodontal disease is a common worldwide oral inflammation/infection affecting tissues that surround and support teeth. This study aims to evaluate the prevalence, extent and severity of periodontal diseases and its risk factors, according to the most recent periodontal classification, in an adult population of Northern Portugal. This observational study collected data from clinical records of patients who att...