5 documents found, page 1 of 1
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker trigger...
Peixoto, A; Ferreira, D; Azevedo, R; Freitas, R; Fernandes, E; Relvas-Santos, M; Gaiteiro, C; Soares, J; Cotton, S; Teixeira, B; Paulo, P; Lima, LBackground: Muscle invasive bladder cancer (MIBC) remains amongst the deadliest genitourinary malignancies due to treatment failure and extensive molecular heterogeneity, delaying effective targeted therapeutics. Hypoxia and nutrient deprivation, oversialylation and O-glycans shortening are salient features of aggressive tumours, creating cell surface glycoproteome fingerprints with theranostics potential. Meth...
Target score—a proteomics data selection tool applied to esophageal cancer iden...
Cotton, S; Ferreira, D; Soares, J; Peixoto, A; Relvas-Santos, M; Azevedo, R; Piairo, P; Diéguez, L; Palmeira, C; Lima, L; Silva, AMN; Santos, LLEsophageal cancer (EC) is a life-threatening disease, demanding the discovery of new biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins hold tremendous potential towards this objective. In the current study, a series of esophageal squamous cell carcinomas (ESCC) and EC-derived circulating tumor cells (CTCs) were screened by immunoassays for the sialyl-Tn (STn) antigen, a g...
Nucleolin-sle a glycoforms as E-selectin ligands and potentially targetable bio...
Fernandes, E; Freitas, R; Ferreira, D; Soares, J; Azevedo, R; Gaiteiro, C; Peixoto, A; Oliveira, S; Cotton, S; Relvas-Santos, M; Afonso, LP; Palmeira, CBackground: Gastric cancer (GC) is a major health burden worldwide, with half of patients developing metastases within 5 years after treatment, urging novel biomarkers for diagnosis and efficient therapeutic targeting. Sialyl-Lewis A (SLeA), a terminal glycoepitope of glycoproteins and glycolipids, offers tremendous potential towards this objective. It is rarely expressed in healthy tissues and blood cells, whi...
Protein glycosylation and tumor microenvironment alterations driving cancer hal...
Peixoto, A; Relvas-Santos, M; Azevedo, R; Santos, LL; Ferreira, JADecades of research have disclosed a plethora of alterations in protein glycosylation that decisively impact in all stages of disease and ultimately contribute to more aggressive cell phenotypes. The biosynthesis of cancer-associated glycans and its reflection in the glycoproteome is driven by microenvironmental cues and these events act synergistically toward disease evolution. Such intricate crosstalk provide...
CD44 glycoprotein in cancer: A molecular conundrum hampering clinical applications
Azevedo, R; Gaiteiro, C; Peixoto, A; Relvas-Santos, M; Lima, L; Santos, L; Ferreira, JACD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently explored for stem cell identification, and associated with chemoresistance and metastasis. However, CD44 is a general designation for a large family of splicing variants exhibiting different degrees of glyco...