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Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neu...
Bastard, Paul; Vazquez, Sara E.; Liu, Jamin; Laurie, Matthew T.; Wang, Chung Yu; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Zamecnik, ColinLife-threatening "breakthrough" cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; their contribution to hypoxemic breakthrough cases in vaccinated people is unknown. We studied a cohort of 48 ...
Generation, characterization and immunogenicity of a novel chimeric recombinant...
Rocha, Mariana Vilela; Francoso, Katia Sanches; Lima, Luciana Chagas; Camargo, Tarsila Mendes; Machado, Ricardo Luis Dantas; Costa, Fabio T. MThis work was supported by grants from Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq 475500/2012-1), Instituto Nacional de Ci?ncia e Tecnologia de Vacinas (INCTV), Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (FAPESP 2012/13032-5). MVR was sponsored by FAPESP fellowships (2011/23278-9 and 2013/01487-0). RLDM, FTMC and ISS are recipients of fellowships from CNPq.; Universidade de S?...