26 documents found, page 1 of 3
New follow-up methodologies for acute leukemias in allogenic hematopoietic stem...
Serra, C.; Martins, G.; Fernandes, B.; Godinho, I.; Palmeira, C.; Sousa, M.E.Background: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is considered a potential therapy for long-term survival, used as post-remission therapy in leukemias whose response to earlier treatments was not effective. Relapse and associated disease progression are some of the main complications after the transplantation period that may lead to uncertain clinical endings. Transplantation monitorin...
Computational approaches for the automatic quantification of cells from brain i...
Lopes, Diogo; Campos, Ana Bela; Maciel, P.; Novais, Paulo; Fernandes, B.Microglia are glial cells residing in the central nervous system (CNS). They represent the first line of immune defence within the CNS and are responsible for fundamental physiological and pathological processes. Given their importance, the quantification of these cells is fundamental in a clinical context. However, this process is a major challenge, as conventional cell counting involves a specific set of tool...
Designing vocational training policies in an outermost European region: Highlig...
Bettencourt, L.; Simões, F.; Fernandes, B.; Fonseca, J.This paper presents a systematic framework of the most needed Vocational Education and Training (VET) reforms in The Azores, a Portuguese outermost region. Our report is based on a participatory research approach involving the perspectives of five different groups of stakeholders. Our data was collected in 18 virtual world-café sessions (n = 164 participants—58 trainees; 21 trainers; 42 institutional representa...
Improving non-small-cell lung cancer survival through molecular characterizatio...
Fernandes, M. G. O.; Vilariça, A. S.; Fernandes, B.; Camacho, C.; Saraiva, C.; Estevinho, F.; Bastos, H. Novais e; Lopes, J. M.; Fidalgo, P.The management of NSCLC remains challenging, and the integration of data from predictive biomarkers in routine clinical practice can contribute to an optimal, individualized patient approach, particularly given the rapid emergence of effective targeted therapies. When considering molecular biomarker testing, the choice of the biomarker panel, target population, testing approach, and turnaround time are key issu...
Equal opportunities, fair work and social protection: Impacts of COVID-19 on yo...
Simões, F.; Carmo, R. M.; Fernandes, B.Several international organizations, as well as worldwide scholarship, have abundantly shown that young people under 34 are among the groups struggling the most with COVID-19 economic and social impacts. Seldom, however, does scholarship focus on the uneven effects of the pandemic on younger generations across different types of territories. Overall, young people in rural territories tend to face much greater a...
A tree-based approach to forecast the total nitrogen in wastewater treatment pl...
Faria, Carlos; Oliveira, Pedro; Fernandes, B.; Aguiar, Francisco; Pereira, M. A.; Novais, PauloWith the increase in the world population, there has been an increase in environmental problems worldwide. One of these problems is the quality of the water, which can cause problems to society’s well-being and the environments surrounding it. Wastewater Treatment Plants (WWTPs) emerged to address this problem. It is necessary to pay attention to the different substances present in the waterwaters treated in th...
Profiling microglia in a mouse model of Machado-Joseph disease
Campos, Ana Bela; Silva, Sara Carina Duarte; Fernandes, B.; Neves, Sofia Pereira; Marques, Fernanda; Castro, Andreia Cristiana TeixeiraMicroglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs. Yet, the microglial profile in Machado–Joseph disease (MJD) remains unexplored. Here, we characterized the profile of microglia in the CMVMJD135 mouse model of MJD. This characterization was performed using primary microglial cultur...
A multi-agent system for automated machine learning
Fernandes, B.; Novais, Paulo; Analide, CesarMachine Learning (ML) focuses on giving machines the ability to forecast, predict, or classify without being explicitly programmed to do so. To achieve such goals, large amounts of data are used to conceive models that can adapt to unseen data and to new scenarios. However, applying ML models to real-world business domains is a resource-intensive and time-consuming effort. Automated machine learning (AutoML) em...
Carbon nanomaterials for electrode modification in CH4-producing bioelectrochem...
Fernandes, B.; Barbosa, Sónia G.; Peixoto, L.; Ter Heijne, Annemiek; Pereira, M. A.Introduction: Unprecedented environmental phenomena have led to emerging and challenging plans to tackle global threats for the humanity namely intensive use of fossil resources and global warming. CO2 emission to the atmosphere is one of the major driver of global climate change. In this context, the development of alternative technologies for carbon capture and utilization has attracting more and more attenti...
Evaluating unidimensional convolutional neural networks to forecast the influen...
Oliveira, Pedro; Fernandes, B.; Aguiar, Francisco; Pereira, M. A.; Novais, PauloOne of our society’s challenges today is water resources management due to its importance for human life. The monitoring of various substances present in wastewater is a crucial part of the process of Wastewater Treatment Plants (WWTPs). One of these substances is the influent’s pH, which plays a fundamental role in the nitrification and nitration processes. Hence, this paper presents a study to forecast the in...