5 documents found, page 1 of 1
Enzyme activities of brown trout liver and kidney peroxisomes after paraquat ex...
Resende, Albina Dolores; Lobo da Cunha, Alexandre; Rocha, EduardoParaquat, a potent herbicide, can be highly toxic to fish, causing morphological and biochemical alterations in several organs, including induction of oxidative stress that may result in cellular damage. Since peroxisomes are vital regulators of reactive oxygen species, it was hypothesized that a subacute exposure of brown trout – a sensitive bioindicator – to a waterborne environmentally relevant concentration...
Lymphocyte population characterization in ovarian cancer microenvironment
Nunes, Ana Rita; Rodrigues, Tomás; Garcez, Fernanda; Ricardo, Sara; Resende, Albina Dolores; Batista-Pinto, CarlaBackground: Ovarian cancer (OC) is one of the most common gynecological cancers, with poor prognosis and high mortality [1]. A key early sign of OC is the presence of ascites [2], indicating transcoelomic metastasis and tumor spread within the peritoneal cavity [3]. The accumulation of this serous fluid facilitates migration of tumor cells, which detach from the primary tumor (PT) in multicellular aggregates, m...
Immune microenvironment of the omentum in appendicitis: a phenotypic perspectiv...
Marques, Sara; Gaspar, Márcio; Garcez, Fernanda; Batista-Pinto, Carla; Ricardo, Sara; Resende, Albina DoloresBackground: The omentum plays a crucial role in managing inflammation and combating infections, particularly in acute appendicitis [1]. This fat-rich fold of the peritoneum contains lymphoid structures known as “Milky Spots”, which house several types of phenotypically and functionally distinct immune cells, including macrophages and lymphocytes, that contribute to its protective function [1,2]. Among these, T ...
Omentum picture: unraveling the enigma of the immune microenvironment in append...
Gaspar, Márcio; Rodrigues, Tomás; Nunes, Ana Rita; Garcez, Fernanda; Ricardo, Sara; Batista-Pinto, Carla; Resende, Albina DoloresBackground: Appendix obstruction triggers inflammation and exaggerated immune responses, leading the omentum, rich in Milky Spots (MS) housing immune cells, to play a vital role in peritoneal immunity. These MS collect antigens and pathogens, inducing immune responses like inflammation, immune tolerance, or fibrosis [1,2]. Their activities, including angiogenesis, stem cell differentiation, and immune resp...
Subcellular distribution of some purine catabolism enzymes in brown trout (Salm...
Resende, Albina Dolores; Rocha, Eduardo; Lobo-da-Cunha, AlexandreBackground: Subcellular location of purine catabolism enzymes is of great interest in comparative studies due to the significant variability among species [1]. This metabolic pathway reflects in large extent a phylogenetic evolution with the loss of several enzymes in certain species, resulting in differences in the end products that are excreted [2]. Particularly in fishes, some of those enzymes are described ...