42 documents found, page 1 of 5
The adaptive immune landscape of the colorectal adenoma–carcinoma sequence
Freitas, JA; Gullo, I; Garcia, D; Miranda, S; Spaans, L; Pinho, L; Reis, J; Sousa, F; Baptista, M; Resende, C; Leitão, D; Durães, C; Costa, JLBackground. The tumor immune microenvironment exerts a pivotal influence in tumor initiation and progression. The aim of this study was to analyze the immune context of sporadic and familial adenomatous polyposis (FAP) lesions along the colorectal adenoma–carcinoma sequence (ACS). Methods. We analyzed immune cell counts (CD3+, CD4+, CD8+, Foxp3+, and CD57+), tumor mutation burden (TMB), MHC-I expression and PD-...
Latin Americans show wide-spread Converso ancestry and imprint of local Native ...
Chacón-Duque, J; Adhikari, K; Fuentes-Guajardo, M; Mendoza-Revilla, J; Acuña-Alonzo, V; Barquera, R; Quinto-Sánchez, M; Gómez-Valdés, JHistorical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry compo...
Cannabis arteritis: ever more important to consider
Santos, RP; Resende, C; Vieira, AP; Brito, CCannabis arteritis (CA) is a major and underdiagnosed cause of peripheral arterial disease in young patients. A 34-year-old man, daily smoker of 20 cigarettes and two cannabis cigarettes for 14 years, presented with a necrotic plaque of left hallux for 3 weeks. The Doppler ultrasound and angiography were compatible with severe Buerger's disease. Submitted to a revascularisation procedure and hypocoagulation wit...
Tungiasis: a poorly-known diagnosis in Europe. Two paradigmatic cases from Port...
Santos, RP; Resende, C; Duarte, ML; Brito, CTungiasis is a cutaneous parasitosis caused by infestation of the skin by gravid fleas of the genus Tunga, mainly Tunga penetrans. This flea is very common in tropical and subtropical regions of the globe, but not in Europe. The infestation is acquired by walking barefoot or lying in places where the flea is present, usually beaches or sandy soils. We report two unrelated cases of imported tungiasis in Portugal...
Sweet's syndrome associated with cellulitis - a challenging diagnosis
Resende, C; Santos, R; Pereira, T; Brito, CSweet's syndrome is a neutrophilic dermatosis with worldwide distribution that has been associated with inflammatory autoimmune diseases, infections, malignancies, drugs, and pregnancy. The disease is idiopathic in up to 50% of patients. A 64-year-old woman, diagnosed with right limb cellulitis (4 days of evolution), was seen at our department, due to persistent cellulitis and progressive appearance of painful ...
A 10-Year Retrospective Analysis of Methyl Aminolevulinate Photodynamic Therapy...
Brito, C; Resende, C; Oliveira, PPhotodynamic therapy (PDT) is a well-established treatment for actinic keratosis (AK), basal cell carcinoma (BCC), and Bowen's disease (BD). The object of this study was to describe the results of a retrospective analysis of patients treated with methyl aminolevulinate PDT (MAL-PDT) with red light, over the past decade at the Hospital de Braga (Braga, Portugal).
A 10-Year Retrospective Analysis of Methyl Aminolevulinate Photodynamic Therapy...
Brito, C; Resende, C; Oliveira, PIntroduction: Photodynamic therapy (PDT) is a well-established treatment for actinic keratosis (AK), basal cell carcinoma (BCC), and Bowen’s disease (BD). The object of this study was to describe the results of a retrospective analysis of patients treated with methyl aminolevulinate PDT (MAL-PDT) with red light, over the past decade at the Hospital de Braga (Braga, Portugal). Methods: This study is based on the...
A Case of IFAP Syndrome with Severe Atopic Dermatitis
Araújo, C; Gonçalves-Rocha, M; Resende, C; Vieira, AP; Brito, CIntroduction. The IFAP syndrome is a rare X-linked genetic disorder characterized by the triad of follicular ichthyosis, atrichia, and photophobia. Case Report. A three-month-old Caucasian, male patient was observed with noncicatricial universal alopecia and persistent eczema from birth. He had dystrophic nails, spiky follicular hyperkeratosis, and photophobia which became apparent at the first year of life. Sh...
Giant congenital melanocytic nevi and neurocutaneous melanosis
Araújo, C; Resende, C; Pardal, F; Brito, CIntroduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnet...
Eczema de contacto alérgico a artroplastias – uma raridade ou uma entidade subd...
Resende, C; Santos, R; Pereira, T; Araújo, C; Tavares, N; Brito, CIntrodução: O eczema de contacto alérgico aos constituintes das próteses ocorre em 1-5% dos doentes e pode ser a causa de falência das artroplastias. Os metais sensibilizantes mais comuns são o níquel, o cobalto e o crómio. Métodos: Estudo retrospectivo dos doentes com artroplastias, submetidos a testes epicutâneos nos últimos 2 anos, com suspeita clinica de eczema de contacto alérgico. Efectuaram-se testes com...