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Up-to-Date Overview of the Use of Natural Ingredients in Sunscreens
Resende, Diana I. S. P.; Jesus, Ana; Lobo, José M. Sousa; Sousa, Emília; Cruz, Maria T.; Cidade, Honorina; Almeida, Isabel F.The photoprotective skincare segment is in high demand to meet consumer concerns on UV-induced skin damage, with a recent trend towards sunscreen alternatives with a natural origin. In this study, the use of natural ingredients, either from terrestrial or marine origin, in a panel of 444 sunscreen commercial formulations (2021) was analyzed. Ingredients from terrestrial organisms represent the large majority fo...
Xanthones for melanogenesis inhibition : Molecular docking and QSAR studies to ...
Rosa, Gonçalo P.; Palmeira, A.; Resende, Diana I. S. P.; Almeida, Isabel F.; Kane-Pagès, Aida; Barreto, Maria do Carmo; Sousa, E.; Pinto, Madalena M. M.The human skin is constantly exposed to external factors that affect its integrity, UV radiation being one of the main stress factors. The repeated exposure to this radiation leads to increased production of Reactive Oxygen Species (ROS) which activate a series of processes involved in photoaging. Excessive UV exposure also exacerbates melanin production leading to a variety of pigmentation disorders. Xanthones...
Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Toward...
Resende, Diana I. S. P.; Almeida, Mariana C.; Maciel, Bruna; Carmo, Helena; Lobo, José Sousa; Dal Pozzo, Carlotta; Cravo, Sara M.; Rosa, Gonçalo P.Antioxidants have long been used in the cosmetic industry to prevent skin photoaging, which is mediated by oxidative stress, making the search for new antioxidant compounds highly desirable in this field. Naturally occurring xanthones are polyphenolic compounds that can be found in microorganisms, fungi, lichens, and some higher plants. This class of polyphenols has a privileged scaffold that grants them severa...
Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
Resende, Diana I. S. P.; Guieu, Samuel; Oliva, Cristina G.; Silva, Artur M. S.A general and efficient asymmetric synthesis of Δ1-pyrrolines by a one-pot nitro-reduction, cyclization, and dehydration of (R,E)-1,5- diphenyl-3-(nitromethyl)-5-pent-4-en-1-ones with iron and aqueous hydrochloric acid has been developed. The Δ1-pyrrolines were obtained with excellent enantioselectivities (up to 99%) and high yields (up to 83%).
Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
Resende, Diana I. S. P.; Guieu, Samuel; Oliva, Cristina G.; Silva, Artur M. S.A general and efficient asymmetric synthesis of (1)-pyrrolines by a one-pot nitro-reduction, cyclization, and dehydration of (R,E)-1,5-diphenyl-3-(nitromethyl)-5-pent-4-en-1-ones with iron and aqueous hydrochloric acid has been developed. The (1)-pyrrolines were obtained with excellent enantioselectivities (up to 99%) and high yields (up to 83%).
Synthesis of 2,6-diary1-1,2-dihydropyridines through a 6 pi-electrocyclization ...
Resende, Diana I. S. P.; Guieu, Samuel; Oliva, Cristina G.; Silva, Artur M. S.The development of an efficient synthetic method toward substituted 1,2-dihydropyridines from cinnamylideneacetophenones is reported. The key intermediates N-sulfonylazatrienes were synthesized through a TiCI4-mediated direct condensation of primary sulfonamides with the substituted (E,E)-cinnamylideneacetophenones. The 6 pi-electrocyclization of these intermediates, catalyzed by a Lewis acid, selectively affor...