9 documents found, page 1 of 1
Feasibility of the expectation-maximization algorithm for assessing individuals...
Oliveira, Larissa Karolina de; Resende, Mariana; Borém, Flávio Meira; Cirillo, Marcelo AngeloThe results of sensory evaluations of coffees are associated with latent factors, such as the particular subjectivity of each individual. Based on the foregoing, assessing the quality of a sensory panel for product discrimination basically depends on the statistical methodology to be used in data analysis. Following this argument, this study aimed to evaluate the feasibility of the EM - Expectation Maximization...
Proposal of a metric selection index for correspondence analysis: an applicatio...
Costa, Adilson Silva da; Resende, Mariana; Nakano, Eduardo Yoshio; Cirillo, Marcelo Angelo; Borém, Flávio Meira; Ribeiro, Diego EgídioCorrespondence analysis is a multivariate dimensionality-reduction technique applied to data structured into contingency tables. The main outcome of this approach is the generation of perceptual maps aimed at the study of similarity between categorical levels. In most cases, interpretations of these similarities present subjectivity when different metrics are considered; e.g., Hellinger distance and Chi-square....
Generalized ridge estimators adapted in structural equation models
Pereira, Gislene Araujo; Resende, Mariana; Cirillo, Marcelo ÂngeloMulticollinearity is detected via regression models, where independent variables are strongly correlated. Since they entail linear relations between observed or latent variables, the structural equation models (SEM) are subject to the multicollinearity effect, whose numerous consequences include the singularity between the inverse matrices used in estimation methods. Given to this behavior, it is natural to und...
Generalized estimating equations to evaluate the dependence of lifetime in conf...
Brighenti, Carla Guimarães; Miranda, Yola Serpa; Resende, Mariana; Cirillo, Marcelo Angelo; Brighenti, Deodoro MagnoOs bioensaios laboratoriais para avaliar o tempo de vida de Apis mellifera têm algumas particularidades, pois cada unidade amostral contém um grupo de abelhas confinadas em uma gaiola. O presente estudo teve como objetivo realizar uma análise longitudinal para avaliar o efeito da dependência do tempo de vida entre abelhas confinadas alimentadas com diferentes dietas. Foi utilizado o método de estimação de equaç...
Bacteriophages as a smart tool to target Alzheimer's Disease
Martins, Ivone M.; Resende, Mariana; Silva, Ana Isabel M.; Lodder, Tessa; Cristóvão, Joana; Gomes, Cláudio M.; Azeredo, Joana; Kessels, Helmut W.Alzheimer's disease is an irreversible, progressive and age-dependent neurodegenerative disorder affecting millions of people worldwide. In our brain, a small sized amyloid-beta (Abeta) peptide, when in excess, progressively aggregates into soluble oligomers and fibrils, to finally deposit and accumulate as insoluble amyloid plaques. The still-soluble Abeta oligomers and fibrils are sufficient to corrupt synapt...
Infection of hematopoietic stem cells by Leishmania infantum increases erythrop...
Carvalho-Gontijo, Raquel; Moreira, Diana Raquel; Resende, Mariana; Costa-Silva, Matheus Fernandes; Peruhype-Magalhães, VanessaImmunosuppression is a well-established risk factor for Visceral Leishmaniasis. Post-immunosuppression leishmaniasis is characterized by an increase of parasite burden, hematopoietic disorders and unusual clinical manifestations. Although there are many reports on bone marrow findings in VL, less is known about the relationship between parasite dynamics in this organ and the function of either hematopoietic ste...
Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common ...
Resende, Mariana; Cardoso, Marcos S.; Ribeiro, Ana R.; Flórido, Manuela; Borges, Margarida; Castro, António G.; Alves, Nuno L.; Cooper, Andrea M.IFN-gamma is known to be predominantly produced by lymphoid cells such as certain subsets of T cells, NK cells, and other group 1 innate lymphoid cells. In this study, we used IFN-gamma reporter mouse models to search for additional cells capable of secreting this cytokine. We identified a novel and rare population of nonconventional IFN-gamma-producing cells of hematopoietic origin that were characterized by t...
The Warburg effect in mycobacterial granulomas is dependent on the recruitment ...
Appelberg, Rui; Moreira, Diana; Silva, Palmira Conceição Araújo Barreira; Borges, Margarida; Silva, Letícia; Dinis-Oliveira, Ricardo JorgeGranulomas are the hallmark of mycobacterial disease. Here, we demonstrate that both the cell recruitment and the increased glucose consumption in granulomatous infiltrates during Mycobacterium avium infection are highly dependent on interferon-y (IFN-y). Mycobacterium avium-infected mice lacking IFN-y signalling failed to developed significant inflammatory infiltrations and lacked the characteristic uptake of ...
Lack of the transcription factor hypoxia-inducible factor (HIF)-1α in macrophag...
Cardoso, Marcos S.; Silva, Tânia M.; Resende, Mariana; Appelberg, Rui; Borges, MargaridaThe establishment of mycobacterial infection is characterized by the formation of granulomas, which are well-organized aggregates of immune cells, namely, infected macrophages. The granuloma's main function is to constrain and prevent dissemination of the mycobacteria while focusing the immune response to a limited area. In some cases these lesions can grow progressively into large granulomas which can undergo ...