9 documents found, page 1 of 1
Progression of capillary hypoperfusion in advanced stages of nonproliferative d...
Marques, Inês Pereira; Reste-Ferreira, Débora; Santos, Torcato; Mendes, Luís; Yamaguchi, Taffeta Ching Ning; Santos, Ana Rita; Pearce, ElizabethTo evaluate the 6-month progression of retinal capillary perfusion in eyes with advanced stages of nonproliferative diabetic retinopathy (NPDR). Design: RICHARD (NCT05112445), 2-year prospective longitudinal study. Participants: Sixty eyes with Diabetic Retinopathy Severity Scale (DRSS) levels 43, 47, and 53 from 60 patients with type 2 diabetes. Fifty-one patients completed the 6-month evaluation. Eyes were ev...
ETDRS grading with CLARUS ultra-widefield images shows agreement with 7-fields ...
Santos, Ana Rita; Ghate, Sejal; Lopes, Marta; Rocha, Ana Cláudia; Santos, Torcato; Reste-Ferreira, Débora; Manivannan, Niranchana; Foote, KatharinaTo analyse and compare the grading of diabetic retinopathy (DR) severity level using standard 35° ETDRS 7-fields photography and CLARUS™ 500 ultra-widefield imaging system. A cross-sectional analysis of retinal images of patients with type 2 diabetes (n=160 eyes) was performed for this study. All patients underwent 7-fields colour fundus photography (CFP) at 35° on a standard Topcon TRC50DX® camera, and ultra-w...
Patterns of progression of nonproliferative diabetic retinopathy using non-inva...
Marques, Inês Pereira; Ribeiro, Maria Luísa; Santos, Torcato; Reste-Ferreira, Débora; Mendes, Luís; Martinho, António Cunha-Vaz; Santos, Ana RitaTo identify progression of nonproliferative diabetic retinopathy (NPDR) in patients with type 2 diabetes by combining optical coherence tomography angiography (OCTA) metrics and color fundus photography (CFP) images. This study was a post hoc analysis of a prospective longitudinal cohort study (CORDIS, NCT03696810) with 2-year duration. This study enrolled 122 eyes. Ophthalmological examinations included OCTA a...
Central and peripheral involvement of the retina in the initial stages of diabe...
Santos, Ana Rita; Almeida, Ana Catarina; Rocha, Ana Cláudia; Reste-Ferreira, Débora; Marques, Inês Pereira; Martinho, António Cunha-Vaz; Mendes, LuísTo determine the degree of central microvascular closure using optical coherence tomography angiography in eyes of patients with type 2 diabetes with visible lesions only in the central retina or only in the periphery. Cross-sectional study. All 127 eyes underwent ultra-widefield fundus photography 200° examinations with OPTOS California (Optos, Dunfermline, United Kingdom) and Cirrus Angioplex optical coherenc...
Different Risk Profiles for Progression of Nonproliferative Diabetic Retinopath...
Marques, Inês; Ribeiro, Maria L.; Santos, Torcato P.; Mendes, Luís G.; Reste-Ferreira, Débora; Santos, Ana R.; Lobo, Conceição L.; Cunha-Vaz, JoséIntroduction: Characterization of 2-year progression of different risk phenotypes in eyes with mild and moderate nonproliferative diabetic retinopathy (NPDR) in type 2 diabetes (T2D). Methods: A 2-year prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted. Ophthalmological examinations were performed including best corrected visual acuity, color fundus photography and optical coherence tomog...
Retinal neurodegeneration in eyes with NPDR risk phenotypes: A two-year longitu...
Reste-Ferreira, Débora; Santos, Ana Rita; Marques, Inês Pereira; Santos, Torcato; Ribeiro, Maria Luísa; Mendes, Luís; Santos, Ana Rita; Lobo, ConceiçãoDiabetic retinopathy (DR) is both a microangiopathy and a neurodegenerative disease. However, the connections between both changes are not well known. To characterise the longitudinal retinal ganglion cell layer + inner plexiform layer (GCL + IPL) changes and their association with microvascular changes in type-2 diabetes (T2D) patients with nonproliferative diabetic retinopathy (NPDR). This two-year prospectiv...
Different risk profiles for progression of nonproliferative diabetic retinopath...
Marques, Inês P.; Ribeiro, Maria L.; Santos, Torcato P.; Mendes, Luis G.; Reste-Ferreira, Débora; Santos, Ana Rita; Lobo, Conceição L.Characterization of 2-year progression of different risk phenotypes in eyes with mild and moderate nonproliferative diabetic retinopathy (NPDR) in type 2 diabetes (T2D). A 2-year prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted. Ophthalmological examinations were performed including best corrected visual acuity, color fundus photography and optical coherence tomography (OCT and OCTA). O...
Retinal capillary nonperfusion in preclinical diabetic retinopathy
Santos, Torcato; Santos, Ana Rita; Almeida, Ana Catarina; Rocha, Ana Cláudia; Reste-Ferreira, Débora; Marques, Inês Pereira; Martinho, António Cunha-VazThe aim of the study was to identify retinal microvascular changes using optical coherence tomography angiography (OCTA) in type 2 diabetes (T2D) patients with preclinical retinopathy identified by ultra-widefield fundus photography (UWF-FP). This is a cross-sectional observational study. All patients underwent UWF-FP 200° examinations with OPTOS California (Optos, Dunfermline, UK) and Cirrus AngioPlex® spectra...
CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function
Esgalhado, AJ; Reste-Ferreira, Débora; Albino, Stephanie; Sousa, Adriana; Amaral, Ana Paula; Martinho, António; Oliveira, Isabel Tomás; Verde, IgnacioThere is increasing evidence that in humans the adaptive immunological system can influence cognitive functions of the brain. We have undertaken a comprehensive immunological analysis of lymphocyte and monocyte populations as well as of HLA molecules expression in a cohort of elderly volunteers (age range, 64-101) differing in their cognitive status. Hereby, we report on the identification of a novel signature ...