Introduction: Chronic infection with hepatitis C virus (HCV) causes 25% of hepatocellular carcinoma (HCC) cases worldwide, a major cause of morbimortality even after sustained virologic response (SVR). Universal screening to all patients with advanced liver fibrosis is currently recommended. A risk-based strategy could improve the detection rate of early HCC and diminish the surveillance burden. Although severa...
Current treatment algorithms in inflammatory bowel disease (IBD) rely on a “trial and error” approach, and therefore, patients may receive ineffective and costly therapy for many months, with associated risks. Furthermore, after failure of the first biologic, response rates to second-line therapies drop considerably. Personalized medicine, which seeks to identify biomarkers that predict disease course and treat...
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