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PEGylated ofloxacin nanoparticles render strong antibacterial activity against ...

Marslin, Gregory; Revina, A. M.; Khandelwal, V. K. M.; Balakumar, K.; Singh, Caroline Jeya Sheeba Daniel Sunder; Franklin, Gregory

The rise of bacterial resistance against important drugs threatens their clinical utility. Fluoroquinones, one of the most important classes of contemporary antibiotics has also reported to suffer bacterial resistance. Since the general mechanism of bacterial resistance against fluoroquinone antibiotics (e.g. ofloxacin) consists of target mutations resulting in reduced membrane permeability and increased efflux...


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