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A study of some hepatic immunological markers, iron load and virus genotype in ...

Cardoso, Elsa M.; Duarte, Miguel A.; Ribeiro, Eduarda; Rodrigues, Pedro; Hultcrantz, Rolf; Sampaio, Paula; Ehrlich, Rachel; Carvalho, João; Fraga, José

BACKGROUND/AIMS: Host factors that may influence progression of hepatitis C infection to chronic hepatitis include T-cell responses and iron accumulation. We evaluated the hepatic expression of immunological markers relevant for a cytotoxic response in relation to viral and HFE genotype. METHODS: Frozen liver biopsies were obtained at diagnosis from 28 HFE genotyped patients. Sections stained for CD8, MHC-I, be...


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