2 documents found, page 1 of 1
Deregulated expression of SRC, LYN and CKB kinases by DNA methylation and its p...
Mello, Adriano Azevedo; Leal, Mariana Ferreira; Rey, Juan Antonio; Pinto, Giovanny Rebouças; Lamarão, Leticia Martins; Montenegro, Raquel CarvalhoKinases are downstream modulators and effectors of several cellular signaling cascades and play key roles in the development of neoplastic disease. In this study, we aimed to evaluate SRC, LYN and CKB protein and mRNA expression, as well as their promoter methylation, in gastric cancer. We found elevated expression of SRC and LYN kinase mRNA and protein but decreased levels of CKB kinase, alterations that may h...
Genetic screening analysis of patients with hereditary diffuse gastric cancer f...
Moreira-Nunes, Caroline Aquino; Barros, Mariceli Baia Leão; Borges, Bárbara do Nascimento; Montenegro, Raquel Carvalho; Lamarão, Leticia MartinsBackground: Hereditary diffuse gastric cancer (HDGC) is a hereditary autosomal inherited syndrome associated with CDH1 germline mutations. In Brazil, gastrointestinal tumors are among the most prevalent tumor types and constitute a serious public health problem, especially in the northern and northeastern regions. This study aimed to investigate germline mutations, methylation pattern and genomic rearrangements...