7 documents found, page 1 of 1
Building fucoidan/agarose-based hydrogels as a platform for the development of ...
Reys, Lara Priscila Lopes; Silva, SS; Soares da Costa, Diana; Rodrigues, Luísa Cidália Guimarães; Reis, R. L.; Silva, Tiago H.Current management for diabetes has stimulated the development of versatile 3D-based hydrogels as in vitro platforms for insulin release and as support for the encapsulation of pancreatic cells and islets of Langerhans. This work aimed to create agarose/fucoidan hydrogels to encapsulate pancreatic cells as a potential biomaterial for diabetes therapeutics. The hydrogels were produced by combining fucoidan (Fu) ...
Sulfated seaweed polysaccharides
Inácio, Ana Rita Matos; Carvalho, Ana C.; Oliveira, Catarina; Reys, Lara Priscila Lopes; Silva, Simone S.; Neves, N. M.; Martins, Albino; Reis, R. L.Mankind has used natural resources for many different applications, from food and clothes to drugs, but only recently is giving the due attention to the need for a responsible management of these resources toward sustainability. One of the approaches is to take the most out of its resources, addressing the several components of natural resources, which can be used in many industrial fields. In this regard, many...
Algae-origin Fucoidan on development of therapeutic approaches for Diabetes Mel...
Reys, Lara Priscila LopesDiabetes mellitus (DM) is a metabolic disorder that affects 450 million people worldwide, being the sixth most common cause of death. Therefore, it is crucial to develop new therapeutic strategies and relevant models for diabetes in order to accelerate the discovery of new treatments. In this perspective, marine origin polymers represent a relatively untapped source that can be used in the creation of platforms...
Angiogenic potential of airbrushed fucoidan/polycaprolactone nanofibrous meshes
Reys, Lara Priscila Lopes; Silva, Simone S.; Oliveira, C.; Neves, N. M.; Martins, Albino; Reis, R. L.; Silva, Tiago H.Implantation of biomaterials and hybrid constructs in tissue engineering approaches presents major limitations such as inflammatory reaction and the lack of vasculature integration. Therefore, new strategies are needed to enhance implant function, immune protection, and revascularization. In this work, we developed fibrous meshes composed of fucoidan (Fu), a sulfated polysaccharide extracted from brown algae, a...
Marine-origin Polysaccharides for tissue engineering and regenrative medicine. ...
Reys, Lara Priscila Lopes; Silva, Simone S.; Oliveira, C.; Cebral, Rita López; Neves, N. M.; Martins, Albino; Oliveira, J. M.; Silva, Tiago H.Marine polysaccharides are receiving wide attention not only from scientists but also from engineering and medical staff, given the several properties being reported for this class of biopolymers and based on the reputation gain by the terrestrial representatives. The marine environment is a source yet to be untapped, with several approaches being disclosed to promote the sustainable exploitation of marine biol...
Evaluation of the potential of fucoidan-based microparticles for diabetes treat...
Reys, Lara Priscila Lopes; Silva, Simone Santos; Oliveira, Nuno M.; Costa, Diana Pereira Soares; Mano, J. F.; Reis, R. L.Abstract INTRODUCTION: Marine organisms have in their constitution materials with a wide range of properties and characteristics inspiring their application within the biomedical field. One important example is fucoidan (Fu), an underexploited sulfated polysaccharide extracted from the cell wall of the brown seaweeds, with high solubility in water1. Fucoidan is composed of L- fucose and glucuronic acid includin...
Biomedical potential of fucoidan, a seaweed sulfated polysaccharide: from a ant...
Silva, Tiago José Quinteiros Lopes Henriques; Oliveira, Catarina; Reys, Lara Priscila Lopes; Costa, Diana Pereira Soares; Novoa-Carballal, R.Marine macroalgae or seaweeds synthesize a wide variety of polymers and smaller compounds with several bioactivities, among which the sulfated polysaccharides acquire greater relevance not only due to the reported antioxidant, antiviral and anticancer[1]Â activities, but also to the resemblance of extracellular matrix glycosaminoglycans found in the human body[2]. In this study, the potential of fucoidan (Fu) i...