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Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone rege...

Vasconcelos, DM; Gonçalves, RM; Almeida, CR; Pereira, IO; Oliveira, MI; Neves, N; Silva, AM; Ribeiro, AC; Cunha, C; Almeida, AR; Ribeiro, CC; Gil, AM

The hypothesis behind this work is that fibrinogen (Fg), classically considered a pro-inflammatory protein, can promote bone repair/regeneration. Injury and biomaterial implantation naturally lead to an inflammatory response, which should be under control, but not necessarily minimized. Herein, porous scaffolds entirely constituted of Fg (Fg-3D) were implanted in a femoral rat bone defect and investigated at tw...


Functional analysis of vif protein shows less restriction of human immunodefici...

Ribeiro, AC; Silva, AME; Silva, AME; Santa-Marta, M; Pombo, A; Moniz-Pereira, J; Goncalves, J; Barahona, I

Viral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and is conserved in the primate lentivirus group. This protein is essential for viral replication in vivo and for productive infection of nonpermissive cell


Characterization of globulins from common vetch (Vicia sativa L.)

Ribeiro, AC; Teixeira, AR; Ferreira, RB

The proteins from Vicia sativa L. (common vetch) seeds were investigated. Protein comprises similar to11.4% of the seed fresh weight, 50.8% of which is composed by globulins and 43.6% by albumins. The globulins may be fractionated into two main components, which were named alpha-vicinin (comprising 73% of the total globulin fraction, and hence 37% of the total seed protein) and beta-vicinin. Two minor globulin ...


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