12 documents found, page 1 of 2
Dhvar5- and MSI78-coated titanium are bactericidal against methicillin-resistan...
Costa, B; Coelho, J; Silva, V; Shahrour, H; Costa, NA; Ribeiro, AR; Santos, SG; Costa, F; Martínez-de-Tejada, G; Monteiro, C; Martins, MCLInfection is one of the major issues associated with the failure of orthopedic devices, mainly due to implant bacterial colonization, biofilm formation, and associated antibiotic resistance. Antimicrobial peptides (AMP) are a promising alternative to conventional antibiotics given their broad-spectrum of activity, low propensity to induce bacterial resistance, and ability to modulate host immune responses. Dhva...
Effect of NaOH etching and oxygen plasma treatments on surface characteristics ...
Costa, NA; Ribeiro, AR; Rossi, AL; Monteiro, C; Lisboa, PN; Martins, MCLActivation treatments such as NaOH etching or O2 plasma can play an essential role in surface conjugation of titanium with biomolecules, providing a better interaction at the bone-implant interface. However, their application on complex titanium dioxide (TiO2) surfaces is still not explored. In this contribution, bioactive and porous TiO2 coatings produced by micro-arc oxidation (MAO) were treated with NaOH etc...
Antineoplastic drugs in urban wastewater: Occurrence, nanofiltration treatment ...
Gouveia, TIA; Cristóvão, MB; Pereira, VJ; Crespo, JG; Alves, A; Ribeiro, AR; Silva, A; Santos, MSFAntineoplastic drugs are pharmaceuticals that have been raising concerns among the scientific community due to: (i) their increasing prescription in the fight against the disease of the twentieth century (cancer); (ii) their recalcitrance to conventional wastewater treatments; (iii) their poor environmental biodegradability; and (iv) their potential risk to any eukaryotic organism. This emerges the urgency in f...
Portuguese recommendations for the use of biological and targeted synthetic dis...
Fernandes, Bruno Miguel; Guimarães, F; Almeida, DE; Neto, A; Tavares-Costa, J; Ribeiro, AR; Quintal, Alberto; Pereira, JP; Silva, L; Nóvoa, TSObjective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consen...
Thymic crosstalk restrains the pool of cortical thymic epithelial cells with pr...
Meireles, C; Ribeiro, AR; Pinto, RD; Leitão, C; Rodrigues, PM; Alves, NLCortical (cTEC) and medullary (mTEC) thymic epithelial cells establish key microenvironments for T-cell differentiation and arise from thymic epithelial cell progenitors (TEP). However, the nature of TEPs and the mechanism controlling their stemness in the postnatal thymus remain poorly defined. Using TEC clonogenic assays as a surrogate to survey TEP activity, we found that a fraction of cTECs generates specia...
Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common ...
Resende, M; Cardoso, MS; Ribeiro, AR; Flórido, M; Borges, M; Castro, AG; Alves, NL; Cooper, AM; Appelberg, RIFN-γ is known to be predominantly produced by lymphoid cells such as certain subsets of T cells, NK cells, and other group 1 innate lymphoid cells. In this study, we used IFN-γ reporter mouse models to search for additional cells capable of secreting this cytokine. We identified a novel and rare population of nonconventional IFN-γ-producing cells of hematopoietic origin that were characterized by the expressio...
Thymic epithelial cells require p53 to support their long-term function in thym...
Rodrigues, PM; Ribeiro, AR; Perrod, C; Landry, JJM; Araújo, L; Pereira-Castro, I; Benes, V; Moreira, A; Xavier-Ferreira, H; Meireles, C; Alves, NLThymic epithelial cells (TECs) provide crucial microenvironments for T-cell development and tolerance induction. As the regular function of the thymus declines with age, it is of fundamental and clinical relevance to decipher new determinants that control TEC homeostasis in vivo. Beyond its recognized tumor suppressive function, p53 controls several immunoregulatory pathways. To study the cell-autonomous role o...
Thymus medulla under construction: Time and space oddities
Alves, NL; Ribeiro, ARThe development of effective T-cell-based immunotherapies to treat infection, cancer, and autoimmunity should incorporate the ground rules that control differentiation of T cells in the thymus. Within the thymus, thymic epithelial cells (TECs) provide microenvironments supportive of the generation and selection of T cells that are responsive to pathogen-derived antigens, and yet tolerant to self-determinants. D...
Lymphotoxin-β receptor in microenvironmental cells promotes the development of ...
Fernandes, MT; Ghezzo, MN; Silveira, AB; Kalathur, RK; Póvoa, V; Ribeiro, AR; Brandalise, SR; Dejardin, E; Alves, NL; Ghysdael, J; Barata, JT; Yunes, JALymphotoxin-mediated activation of the lymphotoxin-β receptor (LTβR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we show that the genes encoding lymphotoxin (LT)-α and LTβ (LTA, LTB) are expressed in T-ALL patient samples, mostly of the TAL/LMO molecular subtype, and in the TEL-JAK2 transgenic mouse model of cortical/mature T-ALL (...
Intermediate expression of CCRL1 reveals novel subpopulations of medullary thym...
Ribeiro, AR; Meireles, C; Rodrigues, PM; Alves, NLCortical and medullary thymic epithelial cells (cTECs and mTECs, respectively) provide inductive microenvironments for T-cell development and selection. The differentiation pathway of cTEC/mTEC lineages downstream of common bipotent progenitors at discrete stages of development remains unresolved. Using IL-7/CCRL1 dual reporter mice that identify specialized TEC subsets, we show that the stepwise acquisition of...