5 documents found, page 1 of 1
Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhib...
Pires, Ana S.; Marques, Cláudia R.; Encarnação, João C.; Abrantes, Ana M.; Marques, Inês A.; Laranjo, Mafalda; Oliveira, Rui; Lopes, João E. CasaltaColorectal cancer (CRC) is continuously classified as one of the most incidental and mortal types of cancer worldwide. The positive outcomes of the conventional chemotherapy are frequently associated with high toxicity, which often leads to the suspension of the treatment. Growing evidences consider the use of pharmacological concentrations of ascorbic acid (AA), better known as vitamin C, in the treatment of c...
Tissular growth factors profile after teduglutide administration on an animal m...
Costa, Beatriz P.; Gonçalves, Ana C.; Abrantes, Ana M.; Alves, Raquel; Matafome, Paulo N.; Seiça, Raquel; Ribeiro, Ana B. Sarmento; Botelho, M. FilomenaBackground: Teduglutide is an enterotrophic analogue of glucagon-like peptide-2, with an indirect and poorly understood mechanism of action, approved for the rehabilitation of short-bowel syndrome. This study aims to analyze the response of tissue growth factors to surgical injury and teduglutide administration on an animal model of intestinal anastomosis. Methods: Wistar rats (n = 59) were distributed into fou...
Effects of resistance exercise on endothelial progenitor cell mobilization in w...
Ribeiro, Fernando; Ribeiro, Ilda P.; Gonçalves, Ana C.; Alves, Alberto J.; Melo, Elsa; Fernandes, Raquel; Costa, Rui; Ribeiro, Ana B. SarmentoThis study aimed to determine the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating EPCs over 24 hours in women. In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1α), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α) and erythropoietin (EPO) were measured as potential mechanisms for exercise-induced...
Eritropoietina Sérica como Marcador Prognóstico em Síndrome Mielodisplásica
Cortesão, Emília; Tenreiro, Rita; Ramos, Sofia; Pereira, Marta I.; César, Paula; Carda, José P.; Gomes, Marília; Rito, Luís Carlos; Magalhães, EmíliaIntrodução: A síndrome mielodisplásica é uma doença heterogénea caracterizada por displasia, medula hipercelular, citopenias e risco de evolução para leucemia aguda. Outros factores de prognóstico, nomeadamente, fibrose medular, elevação da enzima desidrogenase do lactato e β2-microglobulina têm sido descritos, contudo, a decisão terapêutica baseia-se no score do International Prognostic Scoring System. Materia...
Serum Erythropoietin as Prognostic Marker in Myelodysplastic Syndromes
Cortesão, Emília; Tenreiro, Rita; Ramos, Sofia; Pereira, Marta; César, Paula; Carda, José P.; Gomes, Marília; Rito, Luís; Magalhães, EmíliaIntroduction: This myelodysplastic syndromes are a heterogeneous entity characterized by dysplasia, hypercellular bone marrow, cytopenias and risk of transformation to acute leukaemia. Prognostic factors, such as bone marrow fibrosis, lactate dehydrogenase and β2-microglobulin elevation have been described, but treatment is mainly based in the International Prognostic Scoring System.Material and Methods: Our ai...