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Brain-derived neurotrophic factor mediates neuroprotection against Aβ-induced t...

Jerónimo-Santos, André; Fonseca-Gomes, João; Guimarães, Diogo Andrade; Tanqueiro, Sara; Ramalho, Rita Mira; Ribeiro, Joaquim A.; Sebastião, Ana M

Brain-derived neurotrophic factor (BDNF) promotes neuronal survival through TrkB-FL activation. The activation of adenosine A2A receptors (A2AR) is essential for most of BDNF-mediated synaptic actions, such as synaptic plasticity, transmission and neurotransmitter release. We now aimed at evaluating the A2AR influence upon BDNF-mediated neuroprotection against Aβ25-35 toxicity in cultured neurons. Results showe...

Date: 2015   |   Origin: Repositório da Universidade de Lisboa
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