4 documents found, page 1 of 1
PVP formulations of bis-cyclometalated iridium(III) complexes bearing β-modifie...
Moura, Nuno M. M.; Reis, Melani J. A.; Lodeiro, Carlos; Neves, M. Graça P. M. S.; Cavaleiro, José A. S.; Ribeiro, Carlos F.; Fernandes, RosaCancer stands as the second leading global cause of death, following heart disease. Considering the severe side effects revealed by some chemotherapeutics for tumor treatment and anticancer therapies, the scientific community is actively exploring more effective alternatives. Photodynamic Therapy (PDT) mediated by porphyrin-based photosensitizers (PS) has emerged as an attractive alternative to more conventiona...
Unraveling the photodynamic activity of cationic benzoporphyrin-based photosens...
Gomes, Ana T. P. C.; Neves, M. Graça P. M. S.; Fernandes, Rosa; Ribeiro, Carlos F.; Cavaleiro, José A. S.; Moura, Nuno M. M.In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to gener...
Effect of hypoproteic and high-fat diets on hippocampal blood-brain barrier per...
Aquino, Cristhyane Costa de; Leitão, Ricardo A.; Alves, Luis Antonio de Oliveira; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F.Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...
Reduced levels of circulating endothelial progenitor cells in acute myocardial ...
António, Natália; Fernandes, Rosa; Soares, Ana; Soares, Francisco; Lopes, Ana; Carvalheiro, Tiago; Paiva, Artur; Pêgo, Guilherme M.Background: Diabetic patients have a significantly worse prognosis after an acute myocardial infarction (AMI) than their counterparts. Previous studies have shown that the number of circulating endothelial progenitor cells (EPCs) significantly increase early after an AMI in normoglycemic patients. However, it is well known that type 2 diabetes mellitus (DM) is associated with impaired function and reduced circu...