3 documents found, page 1 of 1
Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosens...
Gomes, Ana T. P. C.; Neves, M. Graça P. M. S.; Fernandes, Rosa; Ribeiro, Carlos F. M.; Cavaleiro, José A. S.; Moura, Nuno M. M.In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2'-bipyridine)dichloroplatinum(II) and of the analogs' derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to gener...
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Ce...
Gomes, Ana T. P. C.; Fernandes, Rosa; Ribeiro, Carlos F. M.; Tomé, João P. C.; Neves, Maria G. P. M. S.; Silva, Fernando de C. da; Ferreira, Vítor F.Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of al...
Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Per...
de Aquino, Cristhyane Costa; Leitão, Ricardo A.; Oliveira Alves, Luís A.; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F. M.Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...