11 documents found, page 1 of 2
Improvement in circulating endothelial progenitor cells pool after cardiac resy...
Cristovão, Gonçalo; Milner, James; Sousa, Pedro; Ventura, Miguel; Cristóvão, João; Elvas, Luís; Paiva, Artur; Gonçalves, Lino; Ribeiro, Carlos FontesBackground: Recent studies suggest that circulating endothelial progenitor cells (EPCs) may influence the response to cardiac resynchronization therapy (CRT). The aim of this study was to evaluate the effect of CRT on EPC levels and to assess the impact of EPCs on long-term clinical outcomes. Population and methods: Prospective study of 50 patients submitted to CRT. Two populations of circulating EPCs were quan...
In July 2019 the Portuguese Society of Myology was officially born: the first m...
Tavares, Paula; Ribeiro, Carlos FontesThe amazing behaviour and adaptation capacity of the skeletal muscle system call the attention of several scientists, including us. Thus, we have the pleasure to announce that it was born in the city of Coimbra, Portugal, the Portuguese Society of Myology (SPMyo), a society which the main aim is to spread skeletal muscle knowledge in the areas of muscle physiology, physiopathology and pharmacology in a multidis...
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, Alexandre; Lages, Adriana De Sousa; Andrade, Renato; Ribeiro, Carlos Fontes; Mota-Pinto, Anabela; Carrilho, FranciscoWorld population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered inter...
Aging Hallmarks: the benefits of physical exercise
Rebelo-Marques, Alexandre; De Sousa Lages, Adriana; Andrade, Renato; Ribeiro, Carlos Fontes; Mota-Pinto, Anabela; Carrilho, FranciscoWorld population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered inter...
Intervenções para a aquisição do autocuidado terapêutico da pessoa com diabetes...
Cardoso, Ana Filipa; Queirós, Paulo; Ribeiro, Carlos FontesRESUMO - A prevalência da diabetes em Portugal é de 13,0%, refletindo-se em onerosos custos, que traduzem a forma como cada pessoa se relaciona com a doença. A aquisição de capacidades de autocuidado terapêutico é uma das respostas sobre as quais recaem inúmeras intervenções desenvolvidas por profissionais de saúde. Porém, não existe sistematização sobre intervenções que possam ser globalmente aceites para a pr...
Endothelial progenitor cells in diabetic patients with myocardial infarction – ...
António, Natália; Soares, Ana; Fernandes, Rosa; Soares, Francisco; Lopes, Ana; Carvalheiro, Tiago; Paiva, Artur; Providência, Luís A.; Gonçalves, LinoThe effect of statins on endothelial progenitor cells (EPCs) function derived from diabetic patients (DMpts) with acute myocardial infarction (AMI) is unknown. In this study we assess the response of early and late EPCs from diabetic versus non-diabetic patients (NDMpts) with AMI to statins. EPCs were obtained from 10 diabetic and 10 age-matched non-diabetic male patients with AMI. For each patient, cultures of...
Wastage of medicines in ambulatory care in Portugal
Mendes, Zilda; Crisóstomo, Sofia; Marques, Francisco Batel; Martins, Ana Paula; Rodrigues, Vitor; Ribeiro, Carlos FontesObjective: To characterize the amount of medicines wasted in ambulatory care, Portugal, measured in quantity and value, due to: 1) inadequacy of medicines package sizes to the therapeutic regimen and 2) non-compliance to the treatment prescribed. Study Design: Prospective study. Local: National study carried out between September 2005 and September 2006. Population and Methods: First a questionnaire was adminis...
Desperdício de medicamentos no ambulatório em Portugal
Mendes, Zilda; Crisóstomo, Sofia; Marques, Francisco Batel; Martins, Ana Paula; Rodrigues, Vitor; Ribeiro, Carlos FontesResumo da comunicação apresentada à 10.ª Conferência Nacional de Economia da Saúde
Drug interactions as a preventable cause of iatrogenic disease
Monteiro, Carmen; Marques, Francisco Batel; Ribeiro, Carlos FontesIntroduction: This review considers the basic principles of drug-drug interactions, risk factors and most commonmechanisms underlying drug-drug interactions. Specific examples of drug-drug interactions describedas clinically relevant are also presented. Methods: We searched Medline, Pubmed and B-on for research articles, reviews and meta-analysis. Referenceworks and the European Medicines Evaluation Agency (EME...
Single or multiple injections of methamphetamine increased dopamine turnover bu...
Pereira, Frederico Costa; Lourenço, Elita Santos; Borges, Fernanda; Morgadinho, Teresa; Ribeiro, Carlos Fontes; Macedo, Tice Reis; Ali, Syed F.Methamphetamine (METH), leading to striatal dopamine (DA) nerve terminal toxicity in mammals, is also thought to induce apoptosis of striatal neurons in rodents. We investigated the acute effects induced by multiple injections of METH (4 × 5 mg/kg, i.p.) at 2-h intervals or a single injection of METH (20 mg/kg, i.p.) on terminal dopaminergic toxicity markers, including DA levels, DA turnover, and tyrosine hydro...