3 documents found, page 1 of 1
Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?
Xapelli, Sara Alves; Agasse, Fabienne; Grade, Sofia; Bernardino, Liliana; Ribeiro, Filipa F.; Schitine, Clarissa S.; Heimann, Andrea S.; Ferro, Emer S.Neural stem cells (NSCs) from the subventricular zone (SVZ) have been indicated as a source of new oligodendrocytes to use in regenerative medicine for myelin pathologies. Indeed, NSCs are multipotent cells that can self-renew and differentiate into all neural cell types of the central nervous system. In normal conditions, SVZ cells are poorly oligodendrogenic, nevertheless their oligodendrogenic potential is b...
Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murin...
Xapelli, Sara Alves; Agasse, Fabienne; Sardà-Arroyo, Laura; Bernardino, Liliana; Santos, Tiago; Ribeiro, Filipa F.; Valero, Jorge; Bragança, JoséThe endocannabinoid system has been implicated in the modulation of adult neurogenesis. Here, we describe the effect of type 1 cannabinoid receptor (CB1R) activation on self-renewal, proliferation and neuronal differentiation in mouse neonatal subventricular zone (SVZ) stem/progenitor cell cultures. Expression of CB1R was detected in SVZ-derived immature cells (Nestin-positive), neurons and astrocytes. Stimulat...
Activation of Type 1 Cannabinoid Receptor (CB1R) promotes neurogenesis in murin...
Xapelli, Sara; Agasse, Fabienne; Sarda-Arroyo, Laura; Bernardino, Liliana; Santos, Tiago; Ribeiro, Filipa F.; Valero, Jorge; Braganca, JoséThe endocannabinoid system has been implicated in the modulation of adult neurogenesis. Here, we describe the effect of type 1 cannabinoid receptor (CB1R) activation on self-renewal, proliferation and neuronal differentiation in mouse neonatal subventricular zone (SVZ) stem/progenitor cell cultures. Expression of CB1R was detected in SVZ-derived immature cells (Nestin-positive), neurons and astrocytes. Stimulat...