7 documents found, page 1 of 1
CYP2C19*2 and prognosis after an acute coronary syndrome: Insights from a Portu...
Teixeira, R; Monteiro, P; Marques, G; Pego, J; Lourenço, M; Tavares, C; Reboredo, A; Monteiro, S; Gonçalves, F; Ferreira, MJ; Freitas, M; Ribeiro, GBACKGROUND: Clopidogrel requires oxidation dependent on the cytochrome P450 enzyme 2C19 (CYP2C19) to form its active metabolite. The importance of loss-of-function alleles (particularly CYP2C19*2, 681G>A) in poor platelet response to clopidogrel is well recognized. OBJECTIVE: To investigate the prevalence and prognostic impact of the CYP2C19*2 allele in a local acute coronary syndrome (ACS) population. METHODS:...
Spread of an OmpK36-modified ST15 Klebsiella pneumoniae variant during an outbr...
Novais, A; Rodrigues, C; Branquinho, R; Antunes, P; Grosso, F; Boaventura, L; Ribeiro, G; Peixe, LWe aim to characterise multiple ertapenem-resistant (ERT-R, n = 15) Enterobacteriaceae isolates identified as presumptive carbapenemase producers in a Portuguese hospital in a short period of time (March-July 2010). Antibiotic susceptibility patterns, beta-lactamases, genetic relatedness [pulsed-field gel electrophoresis (PFGE), multi-locus sequence typing (MLST)], plasmid content and major enterobacterial pori...
Appearance of a pandrug-resistant Acinetobacter baumannii causing nosocomial in...
Silva, GJDa; Boaventura, L; Vital, C; Vieira, C; Cardoso, F; Pontes, C; Tome,R; Duarte, A; Ribeiro, G
Detection of OXA-40 carbapenemase in an Acinetobacter baumannii epidemic strain...
Silva, GJDa; Correia, M; Bertolo, E; Vital, C; Ribeiro, G; Duarte, A; Peixe, L
First Appearance of a blaIMP Gene in an Acinetobacter Genospecies 10 Clinical S...
Silva, GJda; Correia, M; Vital, C; Ribeiro, G; Peixe, L; Duarte, A
Molecular characterization of bla(IMP-5), a new integron-borne metallo-beta-lac...
Da Silva, GJ; Correia, M; Vital, C; Ribeiro, G; Sousa, JC; Leitao, R; Peixe, L; Duarte, AAcinetobacter baumannii 65FFC, an imipenem-resistant clinical strain, isolated from the urine of a patient at the Coimbra University Hospital, Portugal, in 1998, produced a metallo-beta-lactamase with a calculated pI 9.3. The isolate was highly resistant to penicillins, broad-spectrum cephalosporins, including ceftazidime, ceftriaxone, cefepime, cefpirome, and to aztreonam, but it remained susceptible to ampici...
Multicenter study of isolated micro-organisms resistant to antimicrobials in 10...
Cristino, J M; Calado, E; Calheiros, I M; Costa, D; Costa, M N; Diogo, J; Felicio, M L; Ferro, M L; Da Fonseca, J C; Guimarães, M A; Lito, L; Marques, JIn 1994, Microbiology Laboratories of ten Portuguese hospitals analysed isolated microorganisms found in blood and urine samples and studied antimicrobial susceptibilities of the most frequent bacterial pathogens. From 63780 blood samples, the most frequent were Staphylococcus spp. and from 69189 urine samples significant numbers of Escherichia coli, Enterococcus spp., Pseudomonas aeruginosa and Candida spp. we...